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EC number: 205-440-9 | CAS number: 140-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- EPI Suite v 4.0/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Daphnid species
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Nominal and measured concentrations:
- not applicable. QSAR model
- Details on test conditions:
- 100% Sodium ethyl xanthate (CAS No. 140-90-9)
SMILES : S=C([S-])OCC.[Na+]
CHEM : Carbonodithioic acid, o-ethyl ester, sodium salt
MOL FOR: C3 H5 O1 S2 Na1
MOL WT : 144.18
Log Kow: 0.87 (used)
Wat Sol: 1.79E+004 mg/L (WskowWin estimate) - Reference substance (positive control):
- not required
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 445.776 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid.
- Executive summary:
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid.
Daphnid , 48-hr LC50 = 445.776 mg/L (ppm)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- EPI Suite v 4.0/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Mysid shrimp
- Details on test organisms:
- Scientific name: Americamysis bahia
Common name: Opossum shrimp, Mysid shrimp, Mysids - Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Nominal and measured concentrations:
- not applicable. QSAR model
- Details on test conditions:
- 100% Sodium ethyl xanthate (CAS No. 140-90-9)
SMILES : S=C([S-])OCC.[Na+]
CHEM : Carbonodithioic acid, o-ethyl ester, sodium salt
MOL FOR: C3 H5 O1 S2 Na1
MOL WT : 144.18
Log Kow: 0.87 (used)
Wat Sol: 1.79E+004 mg/L (WskowWin estimate) - Reference substance (positive control):
- not required
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2 090.966 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 2090.966 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.
- Reported statistics and error estimates:
- Reaction mass of SEX
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 2090.966 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.
- Executive summary:
The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 2090.966 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- NR
- Test temperature:
- 20 °C
- pH:
- 8.4
- Dissolved oxygen:
- O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm. - Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 350 NR TO NR 350 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 350 NR TO NR 350 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.35 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LC10
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC95
- Effect conc.:
- 0.85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- A 24 h EC50 of 0.35 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna .
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile
ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE - Validity criteria fulfilled:
- yes
- Conclusions:
- A 24 h EC50 of 0.35 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna .
- Executive summary:
A 24 h EC50 of 0.35 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna . The The
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- SEX is related compound to PEX
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.1020 (Gammarid Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Gammarus sp.
- Details on test organisms:
- SPECIES #
(NAME): 118 Gammarus sp. (Scud, Amphipod)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 118 to 125 mg/L CaCO3
- Test temperature:
- 10 0C
- pH:
- 7.9 to 8.2
- Dissolved oxygen:
- > 1 mg/L
- Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 52000 NR TO NR 52000 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 52000 NR TO NR 52000 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 52 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE: NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR) - Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 of 52 mg/L has been determined for the effects of the test substance on mortality of the Gammarus sp. (Scud, Amphipod).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The SEX, the subject of this dossier is expected to exhibit very similar toxicity to sodium O-sec-butyl dithiocarbonate (CAS No. 36551-21-0)), which is also xanthate compound. Comparable metabolism would occur.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.1020 (Gammarid Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Gammarus sp.
- Details on test organisms:
- SPECIES #
(NAME): 118 Gammarus sp. (Scud, Amphipod)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 118 to 125 mg/L CaCO3
- Test temperature:
- 10 0C
- pH:
- 7.9 to 8.2
- Dissolved oxygen:
- > 1 mg/L
- Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 8500 NR TO NR 8500 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 8500 NR TO NR 8500 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The SEX, the subject of this dossier is expected to exhibit very similar toxicity to sodium O-sec-butyl dithiocarbonate (CAS No. 36551-21-0)), which is also xanthate compound. Comparable metabolism would occur.
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE: NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR) - Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 of 8.5 mg/L has been determined for the effects of the test substance on mortality of the Gammarus sp.
(Scud, Amphipod).
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to sodium O-sec-butyl dithiocarbonate (CAS No. 36551-21-0)), which is also xanthate compound. Comparable metabolism would occur. - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- NR
- Test temperature:
- 20 °C
- pH:
- 8.4
- Dissolved oxygen:
- O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm. - Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3000 NR TO NR 3000 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3000 NR TO NR 3000 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm.
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC95
- Effect conc.:
- 6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Potassium amyl xanthate (CAS No. 2720-73-2)), which is also xanthate compound. Comparable metabolism would occur.
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile
ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE - Validity criteria fulfilled:
- yes
- Conclusions:
- A 24 h EC50 of 3 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna .
The SEX the subject of this dossier is expected to exhibit very similar toxicity to Potassium amyl xanthate (CAS No. 2720-73-2)), which is also xanthate compound. Comparable metabolism would occur. - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- NR
- Test temperature:
- 20 °C
- pH:
- 8.4
- Dissolved oxygen:
- O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm. - Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3700 NR TO NR 3700 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3700 NR TO NR 3700 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm.
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC95
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Sodium isopropyl xanthate (CAS No. 140-93-2)), which is also xanthate compound. Comparable metabolism would occur.
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile
ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE - Validity criteria fulfilled:
- yes
- Conclusions:
- A 24 h EC50 of 3.7 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Sodium isopropyl xanthate (CAS No. 140-93-2)), which is also xanthate compound. Comparable metabolism would occur. - Executive summary:
A 24 h EC50 of 3.7 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Sodium isopropyl xanthate (CAS No. 140-93-2)), which is also xanthate compound. Comparable metabolism would occur.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- Guideline study without detailed documentation. Incubation carried out in sealed vessels due to volatility of CS2.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- incubation in sealed vessels due to volatility of CS2
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- - Stock solution were prepared fresh each day.
- Test solutions were renewed daily. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- SPECIES #
(NAME): 5 Daphnia magna
(Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: Food: Chlorella pyrenoidosa - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 225 mg CaCO3/L
- Test temperature:
- 20 °C
- pH:
- 8.1
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Nominal and measured concentrations:
- TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGE STANDARD CONC (ug/L) ION
F 2100 1900 TO2200 2100 (1900-2200) ug/L NR - Details on test conditions:
- Tests were carried out in sealed vessels to prevent evaporation of CS2.
The complete compostion of the test medium is given in Van Leeuwen and Maas, Environ. Pollution A37: 105-115 (1985).
Daphnids were fed with algal cells (Chlorella pyrenoidosa), 1E5 cells/mL. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% C.I.: 1.9 - 2.2 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.98 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 3.98 mg/l. (2.1 x 144.19) /76.13 =3.98 mg/l
- Details on results:
- The f SEX, the subject of this dossier is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)), the decomposition product ofReaction mass of SEX. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.98 mg/l. (2.1 x 144.19) /76.13 =3.98 mg/l - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-h EC50 for Daphnia magna in a sealed system was 2.1 mg /L.
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)), the decomposition product of SEX. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.98 mg/l. (2.1 x 144.19) /76.13 =3.98 mg/l - Executive summary:
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)), the decomposition product of SEX. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.98 mg/l. (2.1 x 144.19) /76.13 =3.98 mg/l
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- NR
- Test temperature:
- 20 °C
- pH:
- 8.4
- Dissolved oxygen:
- O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm. - Salinity:
- NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3600 NR TO NR 3600 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3600 NR TO NR 3600 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm.
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 3.01 mg/l. (3.6 x 144.19) /172.24 =3.01 mg/l
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC95
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The SEX the subject of this dossier is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also xanthate compound. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.01 mg/l. (3.6 x 144.19) /172.24 =3.01 mg/l
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile
ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE - Validity criteria fulfilled:
- yes
- Conclusions:
- A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna .
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also xanthate compound. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.01 mg/l. (3.6 x 144.19) /172.24 =3.01 mg/l - Executive summary:
A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna .
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also xanthate compound. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.01 mg/l. (3.6 x 144.19) /172.24 =3.01 mg/l
Referenceopen allclose all
Overview of QSARs estimations on short-term aquatic toxicity of
SEX
to Daphnid
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Daphnid , 48-hr LC50 = 445.776 mg/L (ppm)
Daphnid, 30-day, ChV (chronic value) = 43.190 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid.
Daphnid , 48-hr LC50 = 445.776 mg/L (ppm)
Daphnid, 30-day, ChV (chronic value) =43.190 mg/L (ppm)
Overview of QSARs estimations onshort-term aquatic toxicity of SEX to Mysid shrimp
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Mysid Shrimp, 96 -hr, LC50= 2090.966 mg/L (ppm) Mysid Shrimp (SW), 30-day, ChV (chronic value) = 252.828 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Mysid Shrimp, 96 -hr, LC50= 2090.966 mg/L (ppm)
Mysid Shrimp (SW), 30-day, ChV (chronic value) = 252.828 mg/L (ppm)
Description of key information
A 24 h EC50 of 0.35 mg/L has been determined for the effects of the Sodium ethyl xanthate on immobilation of the Daphnia magna, under the conditions of the study of Xu,Y., J.P. Lay, and F. Korte,1988.
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid. Daphnid , 48-hr LC50 = 445.776 mg/L (ppm)
The available data for marine water short-term to aquatic invertebrate are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10 -5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.
48-hr LC50(Salt water) = 44.6 mg/L (ppm)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.35 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 44.6 mg/L
Additional information
A 24 h EC50 of 0.35 mg/L has been determined for the effects of the Sodium ethyl xanthate on immobilation of the Daphnia magna, under the conditions of the study of Xu,Y., J.P. Lay, and F. Korte,1988.
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 445.776 mg/l therefore that the substance is effectively not toxic to Daphnid. Daphnid , 48-hr LC50 = 445.776 mg/L (ppm)
The available data for marine water short-term to aquatic invertebrate are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.
48-hr LC50(Salt water) = 44.6 mg/L (ppm)
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