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Diss Factsheets
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EC number: 856-079-4 | CAS number: 55860-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- A group of three female Wistar rats were given a single, 24-hour, semi-occluded dermal application of the test item to intact skin at a dose level of 1000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study over a period of 8 days. All animals were subjected to gross necropsy.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-acetyl-2-methylbenzoic acid
- EC Number:
- 856-079-4
- Cas Number:
- 55860-35-0
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 4-acetyl-2-methylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Not reported
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The substance was applied to the intact skin.
- Duration of exposure:
- 24 hours
- Doses:
- 1000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- A group of three female Wistar rats were given a single, 24-hour, semi-occluded dermal application of the test item to intact skin at a dose level of 1000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study over a period of 8 days. All animals were subjected to gross necropsy.
- Statistics:
- Not applicable
Results and discussion
- Preliminary study:
- The dermal LD50 in female Wistar rats was estimated to be >1000 mg/kg bw.
- Mortality:
- No mortality occurred
- Body weight:
- lower than 10% body weight loss
- Gross pathology:
- No abnormalities detected
- Other findings:
- No signs of dermal irritation occurred. The scores for erythema, oedema and other local effects on skin were 'zero' at all time points for all three test animals over a period of 8 days.
Any other information on results incl. tables
Bodyweigt development of test animals
Dose (mg/kg bw) | Animal number | Bodyweight (g), Day 0 | Bodyweight (g), Day 7 | Bodyweight gain (g) |
1000 | 1-0 | 227 | 221 | -6 |
1000 | 1-1 | 226 | 227 | 1 |
1000 | 1-2 | 230 | 222 | -8 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The dermal LD50 value in female Wistar rats was estimated to be >1000 mg/kg bw.
- Executive summary:
In a preliminary acute dermal toxicity study, s group of three female Wistar rats were given a single, 24-hour, semi-occluded dermal application of the test item to intact skin at a dose level of 1000 mg/kg bodyweight. Clinical signs, signs of dermal irritation and bodyweight development were monitored during the study over a period of eight days. All animals were subjected to gross necropsy. No mortality occurred, no clinical signs of toxicity and of dermal irritation occured and no abnormalities were observed at necropsy. There was a small effect on the bodyweight development, with a decrease in bodyweight of less than 10% in two animals, and only minor bodyweight gain in one animal.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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