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EC number: 274-533-4 | CAS number: 70285-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity classification of the target substance ADP (CAS 70285-70-0) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on the available acute toxicity data for the source substances ATP, DI-Na (CAS 987-65-5) and AMP (CAS 61-19-8) and according to the read across justification (see attachment "ADP_70285-70-0_Readacross_Justification” in section 13), the target substance ADP (CAS 70285-70-0) has an LD50 > 2000 mg/kg bodyweight and is therefore not classified for acute toxicity by the oral route according to the EU Regulation on classification, labelling and packaging (CLP) (EC) No 1272/2008.
ATP, DI-Na (CAS 987-65-5)
No death occurred after the single 2000 mg/kg bw oral dose of ATP, Di-Na. In conclusion, the LD50 of the test item ATP, Di-Na (CAS No 987-65-5) is higher than 2000 mg/kg bodyweight by oral route in the rat. According to the results of this study, the test item is not classified for acute toxicity according to the EU Regulation on classification, labelling and packaging (CLP) (EC) No 1272/2008.
AMP (CAS 61-19-8)
No death occurred after the single 2000 mg/kg bw oral dose of AMP. In conclusion, the LD50 of the test item AMP (CAS No 61-19-8) is higher than 2000 mg/kg bodyweight by oral route in the rat. According to the results of this study, the test item is not classified for acute toxicity according to the EU Regulation on classification, labeling and packaging (CLP) (EC) No 1272/2008.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attachment "ADP_70285-70-0_Readacross_Justification" in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occurred at 2000 mg/kg bw single oral dose of ATP, Di-Na. All female rats in step 1 and step 2 survived until the end of the 14-day observation period.
- Clinical signs:
- other: No treatment related symptoms were observed throughout the 14-day post-treatment period at any groups of the female animals.
- Gross pathology:
- All animals survived until the scheduled necropsy on Day 15.
Slight hydrometra was observed in animal No.: 6429 of group 1 and severe hydrometra was recorded in female No.: 6432 of the group 1 and in two females (No.: 6439, 6443) of the group 2. Hydrometra is physiological finding and connected to the cycle of the animal. No pathological changes were found related to the effect of the test item during the macroscopic examination of animals. - Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- No death occurred after the single 2000 mg/kg bw oral dose of ATP, Di-Na. The method used, was not intended for the precise calculation of a precise LD50 value.
The test item was ranked into classes of Globally Harmonized Classification System (GHS) described in the OECD Guideline No. 423 as Category 5.
The test item was ranked into classes of the current EU Regulation on classification, labeling and packaging (CLP) (EC) No 1272/2008 as not classified.
Based on the results of the readacross, also the target substance ADP (CAS 70285-70-0) has an LD50 > 2000 mg/kg bodyweight and is therefore not classified for acute toxicity by the oral route according to the EU Regulation on classification, labelling and packaging (CLP) (EC) No 1272/2008. - Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attachment "ADP_70285-70-0_Readacross_Justification" in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occurred at 2000 mg/kg bw single oral dose of AMP. All female rats in step 1 and step 2 survived until the end of the 14-day observation period.
- Clinical signs:
- other: No treatment related symptoms were observed throughout the 14-day post-treatment period at any groups of the female animals.
- Gross pathology:
- All animals survived until the scheduled necropsy on Day 15.
Severe hydrometra was observed in female No.: 5880 of group 1 and in female No.: 5887 of the group 2. Hydrometra is physiological finding and connected to the cycle of the animal. No pathological changes were found related to the effect of the test item during the macroscopic examination of animals. - Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- No death occurred after the single 2000 mg/kg bw oral dose of AMP (CAS No 61-19-8). The method used, was not intended for the precise calculation of a precise LD50 value.
The test item was ranked into classes of the current EU Regulation on classification, labeling and packaging (CLP) (EC) No 1272/2008 as not classified.
Based on the readacross, also the target substance ADP (CAS 70285-70-0) has an LD50 > 2000 mg/kg bodyweight and is therefore not classified for acute toxicity by the oral route according to the EU Regulation on classification, labelling and packaging (CLP) (EC) No 1272/2008.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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