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EC number: 701-402-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25.03.1992 - 30.11.1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Name: DMPPA_701-402-5
Batch No.: EN 746916/1991
Aggregate State: liquid
Colour: white
Stability: pure: stable for years in solvent: >2 hours in H20, ethanol, methanol, acetone, DMSO, and DMF
Storage: at room temperature
Expiration Date: September, 1996 - Analytical monitoring:
- yes
- Details on sampling:
- 1 ml aliquot of the sample solution was filled up to 50 ml with HPLC water and analysed by HPLC.
- Buffers:
- Sterile buffer solutions for experiments:
pH 4.0: 0.40 ml 0.1N NaOH + 50 ml potassium biphthalate (0.1 mol/1) to 100 ml
pH 7.0: 29.63 ml 0.1N NaOH + 50 ml monopotassium phosphate (0.1 mol/1) to 100 ml
pH 9.0: 21.30 ml 0.1N NaOH + 50 ml boric acid (0.1 mol/1) to 100 ml
The buffer solutions are purged with nitrogen for 5 minutes and heated to 122 °C in an autoclave for 20 minutes for CO2 remove and sterilisation.
The pH of each buffer solution was checked with a calibrated pH meter at required temperature to a precision of at least ± 0.1. - Duration:
- 120 h
- Temp.:
- 50 °C
- Remarks:
- Preliminary test at pH 4, 7 and 9
- pH:
- 7
- Remarks:
- tested at 50, 60 and 70 °C
- pH:
- 9
- Remarks:
- tested at 50 and 30 °C
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- Hydrolysis after 2.4 h at
pH 4: <5 %,
pH 7: 13 %,
pH 9: 49 %
Hydrolysis after 5 days at
pH 4: < 5 %,
pH 7: 42 %,
pH 9: 2 %
DMPPA_701-402-5 is considered hydrolytically stable at pH 4.0 because no hydrolysis reaction was observed until 5 days reaction time (t% >1 year). Therefore, no further tests were performed at pH 4.0. - Transformation products:
- not measured
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- The preliminary study indicates that the substance is hydrolytically stable and no further study was performed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- DMPPA_701-402-5 is hydrolytically stable at pH 4.0, hydrolyses rather slow at pH 7.0 (t1/2 = 189 h), while hydrolysis was relatively fast at pH 9 (t1/2 = 4.6 h).
- Executive summary:
The assessment of hydrolysis of DMPPA_701-402-5 was assessed in a study conducted according to OECD Guideline 106 and EU Method C.7. In the preliminary study, the hydrolysis was assessed at 50 ± 0.1 °C at each of pH 4.0, 7.0, and 9.0. The percentage of hydrolysis was found to be less than 10 % after 5 days (t1/2 >1 year) at pH 4.0, while further testing was needed at at pH 7.0 and 9.0.
DMPPA_701-402-5 is thus considered hydrolytically stable at pH 4.0. During further testing at pH 7.0, the hydrolysis of DMPPA_701-402-5 was found to be rather rather slow (t1/2 = 189 h ). While the hydrolysis reaction of DMPPA_701-402-5 was found to be relative fast at pH 9.0 (t1/2 = 4.6 h).
Reference
Table: Results of the hydrolysis of DMPPA_701-402-5 at pH 7.0
Test no. |
Temp [° C] |
Time [h] |
Conc. (µ.g/ml) |
Hydrolysis [%] |
k* [h-1] |
T1/2 [h] |
1 |
50 |
0 48 72 96 192 264 354 |
2623 2318 2013 1809 1320 981 764 |
12** 23 31 50 63 71** |
0.0026 0.0037 0.0039 0.0036 0.0037 0.0035 |
269.4 188.7 179.0 193.7 186.0 199.0 |
3 |
60 |
0 21 29 |
2365 1593 1411 |
33 40 |
0.0188 0.0178 |
36.8 38.9 |
3 |
70 |
0 6.5 12 21 |
2570 1991 1217 668 |
23** 53 74 |
0.0393 0.0623 0.0641 |
17.7 11.1 10.8 |
slope = k = 0.0037 h-1
intercept = 0.0055
coefficient of regression = 0.999
t1/2 = 0.693/k = 189 h
Table: Results of the hydrolysis of DMPPA_701-402-5 at pH 9.0
Test no. |
Temp [° C] |
Time [h] |
Cone.(µ.g/ml) |
Hydrolysis [%] |
k*[h-1] |
T1/2 [h] |
|
|
0 0.5 |
2585 2467 |
5** |
0.0934 |
7.4 4.4 4.3 4.3 4.4 4.4 4.5 |
1 |
50 |
1 |
2206 |
15** |
0.1586 |
|
|
|
2 |
1869 |
28 |
0.1622 |
|
|
|
3 |
1592 |
38 |
0.1615 |
|
|
|
4 |
1366 |
47 |
0.1594 |
|
|
|
5 |
1174 |
55 |
0.1578 |
|
|
|
6 |
1020 |
61 |
0.1551 |
|
|
30 |
0 43 |
2711 1652 |
39 |
0.0115 |
60.1 |
3 |
|
48 |
1597 |
41 |
0.0110 |
62.9 |
|
|
72 |
1229 |
55 |
0.0110 |
63.1 |
slope = k = 0.1517 h-1
intercept = 0.0266
coefficient of regression = 0.999
t1/2 = 0.693/k = 4.6 h
Description of key information
DMPPA_701-402-5 is hydrolytically stable at pH 4.0, hydrolyses rather slow at pH 7.0 (t1/2 = 189 h), while hydrolysis was relatively fast at pH 9 (t1/2 = 4.6 h).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
The assessment of hydrolysis of DMPPA_701-402-5 was assessed in a study conducted according to OECD Guideline 106 and EU Method C.7. In the preliminary study, the hydrolysis was assessed at 50 ± 0.1 °C at each of pH 4.0, 7.0, and 9.0. The percentage of hydrolysis was found to be less than 10 % after 5 days (t1/2 >1 year) at pH 4.0, while further testing was needed at pH 7.0 and 9.0.
DMPPA_701-402-5 is thus considered hydrolytically stable at pH 4.0. During further testing at pH 7.0, the hydrolysis of FAT 80001/I was found to be rather slow (t1/2 = 189 h). While the hydrolysis reaction of DMPPA_701-402-5 was found to be relative fast at pH 9.0 (t1/2 = 4.6 h).
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