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EC number: 406-250-0 | CAS number: 72619-32-0 HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
- EC Number:
- 406-250-0
- EC Name:
- Methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
- Cas Number:
- 72619-32-0
- Molecular formula:
- C16H13ClF3NO4
- IUPAC Name:
- methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- R Enantiomer of XRD-453 Methyl Ester
Lot # AGR 259823
Purity: 95.7%
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories Inc., Kingston, NewYork
- Age at study initiation: 9 weeks
- Weight at study initiation: Males: 174.0-188.4 g; Females: 133.0-140.4 g
- Fasting period before study: No
- Housing: Individually
- Diet: Purina Certified Rodent Chow # 5002 (Ralston Purina Co., St. Louis, Missouri) ad libitum
- Water: Tap water ad libitum
- Acclimation period: At least one week
- Method of randomisation in assigning animals to test and control groups : Animals were randomly assigned by weight
ENVIRONMENTAL CONDITIONS
- Animal room was designed to maintain adequate environmental conditions concerning temperature and humidity
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- Type of wrap: Plastic wrap covered by a stretch bandage taped
REMOVAL OF TEST SUBSTANCE
- Washing: The skin was washed with mild soap and water, rinsed thoroughly and dried with a soft disposable towel.
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: A careful in-life observation was made and recorded frequently the day of dosing and at least once each working day throughout the two-week observation period. Routine monitoring on weekends/holidays was limited to animal husbandry procedures required to ensure the availability of feed and water. The rats were weighed the day of treatment and on test days 2, 8 and 15.
- Necropsy of survivors performed: yes - Statistics:
- Means and standard deviations were calculated for body weights. The data were evaluated for statistical outliers by a sequential test, however, outliers were not excluded from statistical procedures if found.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: The rats were normal throughout the observation period, with the exception of two males which were lethargic with palpebral closure on test day two only.
- Gross pathology:
- All animals were within normal limits at necropsy.
Applicant's summary and conclusion
- Conclusions:
- Rat dermal LD50 (male/female): >2000 mg/kg
- Executive summary:
Five Fischer 344 rats per sex received a single, dermal 24-hour exposure to 2000 mg of undiluted test substance per kg body weight according to the EPA guideline Subdivision F, 81-2. Parameters examined during the two-week observation period included body weights and in-life observations. All animals were examined for gross pathologic changes.
All animals survived the 2000 mg/kg limit test established by the guidelines and therefore no other dose level was tested. The rats were normal throughout the observation period, with the exception of two males which were lethargic with palpebral closure on test day two only. All rats gained weight by study termination and were within normal limits at necropsy.
It was concluded that, under the conditions of this study, the acute dermal LD50 of the test substance was greater than 2000 mg/kg for male and female rats.
Based on these results, the acute dermal toxicity of the test substance was categorized as low.
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