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Diss Factsheets
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EC number: 206-735-5 | CAS number: 371-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of three F-substituent aromatics in anaerobic systems
- Author:
- Zhi-Qing Zhao
- Year:
- 2 012
- Bibliographic source:
- Wiley Online Library
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Anaerobic biogranules were collected from an internal circulation reactor treating papermaking wastewater. The biogranules were preincubated with sucrose for 3 weeks to improve the activity. The anaerobic toxicity assay wase used to assess the effects of 4-fluoroaniline on methanogensis. It was performed in a series of 300 mL bottles. The sludge was centrifuged at 3000g for 10 min and rinsed three times with oxygen-free water. Then, sludge, 120mL basal medium containing sucrose were transferred into the bottles under anaerobic conditions. 4-Fluoroaniline were added tot the basal medium. All serum bottles were bubbled with pure nitrogen gas for about 1 min to strip air from the serum bottles, and immediately sealed with butyl rubber stoppers and crimped.The initial pH was adjusted to 7.2 ± 0.2. Each level of the test compounds was performed in triplicate. The controls were carried out in the same way without any test compound. All the assays were incubated on a platform shaker at 150 rpm and 30 ± 2 ◦C. CH4 concentration in the headspace of the serum bottles was measured once every 2 h for the first 12 h and once every 12 h thereafter. Samples of 1 mLof gaswere taken with a gas-tight micro-syringe, and immediately analyzed by gas chromatography (GC9800). Three successive feedings to the same sludge were conducted to assess the possible effectof extended exposure of the compounds to anaerobic microorganisms. At the end of the first feeding, the spent media were carefully decanted after deposition for 30 min, and the initial media including the test compounds was reestablished. The third feeding was only the basal mineral medium and sucrose to analyze the residual sludge activity after the first and second exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- anaerobic sludge
Study design
- Test type:
- static
- Water media type:
- not specified
- Total exposure duration:
- 250 h
Test conditions
- Test temperature:
- 30 +- 2 °C
- pH:
- 7.2 +- 0.2
Results and discussion
Effect concentrations
- Duration:
- 250 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 3 200 mg/L
- Basis for effect:
- inhibition of anaerobic gas production
- Remarks:
- Methane production
Applicant's summary and conclusion
- Conclusions:
- Toxic effects of 4-fluoroaniline were observed at 3200 mg/L.
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