Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 629-080-0 | CAS number: 161308-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- other: Expert statement
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- According to conditions described in Column 2 of Section 8.5.2 of Annex VIII testing by the inhalation route is appropriate if exposure of humans via inhalation is likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size. As 4-(cyclohexylamino)butane-1-sulfonic acid is only imported as part of polymers in Europe there is no exposure scenario in which human exposure by inhalation to 4-(cyclohexylamino)butane-1-sulfonic acid particles can occur. Also 4-(cyclohexylamino)butane-1-sulfonic acid is a solid substance with a low vapor pressure (5.5 x 10-8 Pa at 25°C) exposure by inhalation of vapor is unlikely to occur. Since the criteria in Column 2 of Section 8.5.2 are not fulfilled testing by the inhalation route for 4-(cyclohexylamino)butane-1-sulfonic acid is considered not appropriate and thus testing is not performed.
See Cross references for relevant supporting data on uses, toxicological data and physical and chemical properties.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- exposure-related information
Reference
- Justification for no uses reported:
- other: This is a registration according to REACH Article 6(3). The substance is imported as part of polymers only and therefore identified uses are not applicable (in accordance with REACH Article 2(9)).
- Justification for no exposure assessment:
- substance does not meet the criteria for classification as hazardous, nor is assessed to be a PBT or vPvB, as per REACH Article 14(4) during its entire life cycle
- Reason / purpose for cross-reference:
- exposure-related information
Reference
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Vapour pressure at 25°C: <5.5E-8 Pa (EC A.4, OECD 104, OPPTS 830.7950: isothermal thermogravimetric effusion method)
Validation of the method was performed using a set of five reference substances.The log PT versus 1/T curve for the substance over the range 200 - 230°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.
From the measured weight losses in the temperature range 200 - 230°C, the vapour pressure of the substance was determined to be lower than the vapour pressure of reference substancebenzo(ghi)perylene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 1.3E-8 Pa and < 5.5E-8 Pa, resp.
Data source
Reference
- Reference Type:
- other: Expert statement
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An expert statement was prepared
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(cyclohexylamino)butane-1-sulfonic acid
- EC Number:
- 629-080-0
- Cas Number:
- 161308-34-5
- Molecular formula:
- C10 H21 N O3 S
- IUPAC Name:
- 4-(cyclohexylamino)butane-1-sulfonic acid
- Test material form:
- solid
- Details on test material:
- Physical Description: White solid
Storage Conditions: At room temperature
Constituent 1
Results and discussion
Effect levels
- Key result
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Conclusions:
- Based on the expert statement and as the criteria in Column 2 of Section 8.5.2 of REACH are not fulfilled testing by the inhalation route is not performed.
- Executive summary:
According to conditions described in Column 2 of Section 8.5.2 of Annex VIII testing by the inhalation route is appropriate if exposure of humans via inhalation is likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size. As 4-(cyclohexylamino)butane-1-sulfonic acid is only imported as part of polymers in Europe there is no exposure scenario in which human exposure by inhalation to 4-(cyclohexylamino)butane-1-sulfonic acid particles can occur. Also 4-(cyclohexylamino)butane-1-sulfonic acid is a solid substance with a low vapor pressure (5.5 x 10-8 Pa at 25°C) exposure by inhalation of vapor is unlikely to occur. Since the criteria in Column 2 of Section 8.5.2 are not fulfilled testing by the inhalation route for 4-(cyclohexylamino)butane-1-sulfonic acid is considered not appropriate and thus testing is not performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.