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EC number: 500-046-6 | CAS number: 26183-52-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to the Category Approach Justification provided in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.77 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- Source, WoE, C12 - C13 alcohol ethoxylates (EO 6.5), 1999
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.75 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other:
- Remarks:
- Source, WoE, C12 - C13 alcohol ethoxylates (EO 6.5), 1999
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Qualifier:
- according to guideline
- Guideline:
- other: USEPA-TSCA (U.S. EPA, 1992)
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM (1988) guidelines
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: waterflea
- Justification for species other than prescribed by test guideline: no
- Source: stock culture maintained at the University of Mississippi Ecotoxicology Laboratory
- Age of parental stock (mean and range, SD): less than 24 h
- Feeding during test
- Food type: Selenastrum sp. and Ankistrodesmus sp.
- Amount: 5 mL of concentrated algae of above stated species per daphnid
- Frequency: twice daily (in the morning and in the late afternoon)
ACCLIMATION
- Acclimation conditions (same as test or not): daphnids were allowed to acclimate to test temperature prior to introduction into exposure chambers. - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
mean: 77.5 mg/L as CaCO3 (range: 74.0 mg/L - 80.0 mg/L as CaCO3)
Dilution water with an average hardness of approximately 8 mg/L as CaCO3 was adjusted to 80 mg/L as CaCO3 by addition of calcium chloride and sodium bicarbonate.- Test temperature:
- mean: 20.5 °C (range: 19.0 - 22.3 °C)
- pH:
- mean: 8.1 (range: 7.8 - 8.2)
- Dissolved oxygen:
- mean: 8.6 mg/L (range: 6.2 - 9.4 mg/L)
- Nominal and measured concentrations:
- nominal: 0.5, 1.0, 2.0, 3.0 and 6.0 mg/L
mean measured: 0.39, 0.77, 1.75, 2.69 and 5.21 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume: 250 mL borosilicate glass beakers with screened overflow outlets (100 µm mesh) that maintained solution volume at approximately 200 mL.
- Aeration: dilution water was aerated
- Type of flow-through (e.g. peristaltic or proportional diluter): FMI fluid-piston metering pumps (FMI Inc., New York, NY, USA)
- Renewal rate of test solution (frequency/flow rate): flow rates of each chamber were maintained at 2 mL/min by control valves, resulting in approximately 14 volume additions per chamber daily.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: spring water collected daily from the University of Mississippi Biological Field Station.
- Alkalinity: mean: 72.4 mg/L as CaCO3 (range: 70.0 - 75.0 mg/L as CaCO3)
- Conductivity: mean: 325 µ/cm (range: 312 - 349 µ/cm)
- Intervals of water quality measurement: 3 - 5 days during exposure
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h darkness - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.77 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.75 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Details on results:
- - Mortality of parent animals: 97% survival of the control organisms
- No. of offspring produced per day per female: control: see table below
Referenceopen allclose all
Measured concentration |
# Young |
0 |
6.75 |
0.39 |
6.46 |
0.77 |
6.16 |
1.75 |
1.131 |
2.69 |
0.112 |
5.21 |
02 |
1significantly different from control
2not included in reproduction NOEC calculation due to significant survival
effects (significantly different from control)
Description of key information
EC20 (21d) >= 3.72 - <= 6.55 mg/L for Daphnia magna reproduction (QSAR estimation)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.72 mg/L
Additional information
As no study is available for decan-1-ol, ethoxylated, 1-2.5EO (CAS 26183-52-8), a read-across is prepared to a chronic invertebrate study conducted with a similar alcohol ethoxylate (C12-13, 6.5 EO). This 21 days flow-through chronic experiment on Daphnia magna is conducted according to the guidelines USEPA-TSCA (U.S. EPA, 1992) and ASTM (1988) and is well documented in the publication by Gillespie et al. (1999). The reported NOEC for reproduction is 0.77 mg/L.
Nevertheless, the data allow not to derive a precise long-term effect value for the described mixture (decan-1-ol, ethoxylated, 1-2.5EO; CAS 26183-52 -8).
Alcohol ethoxylate specific QSARs were developed to describe the toxicity of varying mixtures (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006). The QSARs considered all three trophic levels (algae, invertebrates and fish). The effects are described as EC20 values, since the QSARs are more robust for the EC20 values than for NOEC or EC10 values (Boeije et al., 2006). For the described mixture decan-1-ol, ethoxylated, 1-2.5EO (CAS 26183-52-8) the QSAR for long-term toxicity on reproduction of Daphnia magna (Boeije et al., 2006) results in an EC20 (21d, reproduction) between 3.72 and 6.55 mg/L. This result is used as key information for the further assessment.
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