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Diss Factsheets
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EC number: 206-406-6 | CAS number: 335-99-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The samples, both validation samples and biological samples, were directly injected and analysed by GC.
- Vehicle:
- no
- Details on test solutions:
- To produce the different test item concentrations appropriate amounts of the stock solution were diluted with dilution water to a volume of 500 mL. 50 mL of the prepared solutions were taken per replicate and 0.5 mL of dilution water containing 5 daphnids was given to all replicates resulting in the final nominal concentrations. For each test item exposure concentration and for the control exposure 4 replicates were prepared.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS, parthenogenetic females, Source : Strain of Bundesgesundheitsamt Berlin
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- The total hardness of the dilution water, measured at test start, was 14.7 °dH (= 262 mg/L CaCO3). The culture and dilution water was prepared and maintained within the specified pH range (6-9), while the hardness fell only slightly outside of the recommended range
(140 – 250 mg/L as CaCO3) specified by the OECD test guideline. - Test temperature:
- 20 +/- 2 °C
- pH:
- 7.9
- Dissolved oxygen:
- 8.8-9.0 mg/l
- Nominal and measured concentrations:
- The results are expressed in terms of geometric mean measured concentrations. Measured test item exposure concentrations ranged from 41.6 % to 78.6 % of their nominal target values at 0 hours and from 41.6 % to 49.2 % of their nominal target values at 48 hours.
- Details on test conditions:
- Test vessels : 100 mL glass beakers covered with watch glasses holding 5 neonates in 50 mL test medium
Experimental design : 9 test concentrations plus 1 control
5 neonates per vessel, 4 replicates per concentration/control
no feeding during the exposure period
static system
Method of initiation : neonates were placed in prepared media
Photoperiod : 16 h light : 8 h dark
Temperature of incubation unit : 19.7 to 20.0 °C - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 27 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The Daphnia were exposed to a range of concentrations, nominally 0.16, 0.31, 0.63, 1.25, 2.5, 5, 10, 20 and 40 mg/L of 1H,1H,7H-perfluoroheptane-1-ol dissolved in dilution water. Auxiliaries used to prepare the test media was a magnetic stirrer.
Observations were made on the swimming ability and the percentage immobilised, respectively, after 24 and 48 hours of exposure. - Validity criteria fulfilled:
- yes
- Conclusions:
- The substance has an EC50 of 27 mg/l (based on mobility) towards daphnia magna, based on an OECD 202 guideline study.
- Executive summary:
The substance has an EC50 of 27 mg/l (based on mobility) towards daphnia magna, based on an OECD 202 guideline study.
Reference
Description of key information
The substance has an EC50 of 27 mg/l (based on mobility) towards daphnia magna, based on an OECD 202 guideline study.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 27 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.