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EC number: 202-635-0 | CAS number: 98-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- α,α,α-trifluorotoluene
- EC Number:
- 202-635-0
- EC Name:
- α,α,α-trifluorotoluene
- Cas Number:
- 98-08-8
- Molecular formula:
- C7H5F3
- IUPAC Name:
- α,α,α-trifluorotoluene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.8 - 3.1 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Amount / concentration applied:
- - Amount(s) applied: 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 2 weeks
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Skin of back and sides.
SCORING SYSTEM:
The findings at test sites were evaluated 30 and 60 min after the end of exposure and after 24, 48 and 72 hours. The findings were expressed numerically in accordance with the Draize scheme.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- other: eschar score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Irritant / corrosive response data:
- Areas of very mild edema and mild to moderate erythema were observed in all rabbits up to 72 hours after application. While the erythema and edema had almost completely disappeared by the end of the observation period, the skin surface remained dry and rough, and was parchment-like and flaky in parts. Scab formation was seen in 1 animal after 7 days. The average irritation value was 2.0 for erythema and eschar formation and 0.2 for edema formation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is considered to be not irritating to rabbit skin.
- Executive summary:
The primary skin irritation potential of the test item was investigated by topical application of 0.5 mL to skin of the back and sides of each of three young adult New Zealand White rabbits in an OECD 404 study. The duration of treatment was four hours. The scoring of skin reactions was performed 0.5, 1, 24, 48 and 72 hours after removal of the dressing. The scores of each animal at the following reading times (24, 48, 72 hours) were used in calculating the respective mean values for each type of lesion. Areas of very mild edema and mild to moderate erythema were observed in all rabbits up to 72 hours after application. While the erythema and edema had almost completely disappeared by the end of the observation period, the skin surface remained dry and rough, and was parchment-like and flaky in parts. Scab formation was seen in 1 animal after 7 days. The average irritation value was 2.0 for erythema and eschar formation and 0.2 for edema formation. The test item was accordingly assessed as a mild skin irritant in rabbits. No corrosive effects were noted on the treated skin of any animal at any measuring interval. Based upon the above results, the test item is considered to be not irritating to rabbit skin.
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