Registration Dossier
Registration Dossier
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EC number: 230-908-4 | CAS number: 7365-82-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The CAESAR model within the VEGA QSAR software predicted that the substance is not mutagenic.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to QPRF/QMRF documentation for detailed information on model suitability.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Version / remarks:
- May 2008
- GLP compliance:
- no
- Type of assay:
- other: QSAR calculation
- Specific details on test material used for the study:
- SMILES: O=C(N)CNCCS(=O)(=O)O
- Species / strain / cell type:
- bacteria, other: modeling based on bacteria
- Metabolic activation:
- not applicable
- Key result
- Species / strain:
- bacteria, other: modeling based on bacteria
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not examined
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- other: QSAR Modeling predicition
- Remarks:
- Negative for mutagenicity.
- Conclusions:
- The CAESAR model within the VEGA QSAR software predicted that N-(carbamoylmethyl) taurine is not mutagenic.
- Executive summary:
The CAESAR model within the VEGA QSAR software predicted that N-(carbamoylmethyl) taurine is not mutagenic.
Reference
See QPRF/QMRF
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available information from an in silico model conducted on the substance, the substance is not classified for mutagenic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
