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Diss Factsheets
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EC number: 200-906-8 | CAS number: 75-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are no experimental data available for 2,2-dimethylbutane therefore Petrotox (v3.06) has been used to estimate aquatic toxicity. Experimental data is available for n‑hexane and iso‑hexane. This data is used for read-across to 2,2 -dimethylbutane.
The Petrotox computer model (v. 3.06), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Short-term toxicity to fish:
A QSAR prediction using Petrotox v3.06 predicted an acute LL50 for fish of 2.12 mg/l, which is considered the key value for acute fish toxicity.
This is supported by and experimental study on the read-across substance n-hexane which reported an LC50 for acute toxicity in fish of >1000 mg/l.
Short-term toxicity to aquatic invertebrates:
A QSAR prediction using Petrotox v3.06 predicted an acute LL50 for invertebrates of 3.68 mg/l, which is considered the key value for acute invertebrate toxicity.
This is supported by and experimental study on the read-across substance n-hexane which reported a 48-hr LC50 for daphnia of 45 mmol/m3 (WAF).
Toxicity to aquatic algae and cyanobacteria:
A QSAR prediction using Petrotox v3.06 predicted an acute LL50 for algae of 1.56 mg/l, which is considered the key value for algae toxicity.
This is supported by two experimental studies on the read-across substance n-hexane which reported an ErL50 of 55 mg/L, EbL50 of 26 mg/L and a NOEL of 30 mg/L based on growth rate in one study and an EC50of 2.66% v/v of test substance.
Toxicity to microorganisms:
A QSAR prediction using Petrotox v3.06 predicted an acute LL50 for algae of 8.12 mg/l, which is considered the key value for toxicity to microorganisms.
There are no experimental studies available for any of the read-across substances.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.