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EC number: 948-208-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 23, 2018 - January 26, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Remarks:
- The test item concentration in the reconstituted water was not quantified at the start and the end of this study. Because of its insolubility in water, the compound cannot be detected with standard analytical methods.
- Vehicle:
- yes
- Remarks:
- Reconstituted water (ELENDT M4 medium)
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- A stock preparation with a test item concentration of 100 mg/L was freshly prepared. For that purpose, the test item was weighed in a calibrated flask and vehicle was added. The preparation was stirred with a magnetic stirrer for 24 hours. Then the formulation was passed through a fitter membrane (pore size: 0.2 μm). The filtrate was used for the study. The pH was not adjusted. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Daphnia magna Straus
- Source: IBACON GmbH (Roßdorf, Germany)
- Age of parental stock (mean and range, SD): until about 6 weeks old
- Feeding during test: no
ACCLIMATION
- Acclimation conditions: same as test
- Type and amount of food: ad libitum with unicellular green algae Pseudokirchneriella subcapitata
- Feeding frequency: three times per week
- Health during acclimation (any mortality observed):
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: Offspring are removed from the vessels at least twice per week. At the start of the experimental phase the daphnids were cautiously removed using a pipette, separated from the reconstituted water using a fine-mesh sieve, and transferred into the test vessels containing test media (test item group) or reconstituted water (control group). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 236 mg CaCO3/L
- Test temperature:
- 20.7 to 21.1°C
- pH:
- 7.71 - 7.80
- Dissolved oxygen:
- 8.16 - 8.61 mg O2/L
- Salinity:
- NA
- Conductivity:
- 744 µS/cm
- Nominal and measured concentrations:
- 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessels
- Type: open
- Material, size, fill volume: glass, 20 mL, 20 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water (ELENDT M4 medium) according to OECD Guideline
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light/ 8 hours darkness
- Light intensity: 589 Lux and 583 Lux prior to and at the end of the exposure period, respectively
EFFECT PARAMETERS MEASURED:
VEHICLE CONTROL PERFORMED: yes/no
RANGE-FINDING STUDY
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: No immobilization was observed at a concentration of 100 mg/L under open static conditions. - Reference substance (positive control):
- no
- Remarks:
- No positive control used in this study. The accuracy and reliability of the test method is demonstrated periodically as recommended by guidelines with potassium dichromate.
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Other adverse effects control: no
- Any observations that might cause a difference between measured and nominal values: no: - Results with reference substance (positive control):
- - Results with reference substance valid?
Yes
- Relevant effect levels: Immobilization
- Limit test: no
- Dose-response test: Yes
- ECx: 48-h EC50 = 0.86 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study, an aqueous solution of nominal 100 mg/L of the test item revealed no toxicity to daphnids. The 48h EC50 was > 100 mg/L (nominal) and, thus, could not be deterrnined in this study.
- Executive summary:
The objective of this study was to determine the effect of the test item on the immobilization of Daphnia magna according to OECD Guideline 201.
Juvenile daphnids were exposed to a nominal test item concentration of 100 mg/L (limit test) in an open static system. 20 daphnids, divided into four replicates, each with five animals were used in the test item group and the control group. The daphnids were observed for immobilization after 24 and 48 hours of exposure.
The test item concentration in the reconstituted water was not quantified at the start and the end of this study. Because of its insolubility in water, the compound cannot be detected with standard analytical methods and the development of an analytical method with a sufficiently low detection and quantification limit is complex. Due to the absence of any adverse effects at the saturation concentration, the study was perforrned without analytical concentration verification.
No effect on the mobility of the daphnia was observed at a nominal concentration of 100 mg/L.
Under the conditions of the present study, an aqueous solution of nominal 100 mg/L of the test item revealed no toxicity to daphnids. The 48h EC50 was > 100 mg/L (nominal) and, thus, could not be deterrnined in this study.
Reference
Description of key information
Under the conditions of the present study, an aqueous solution of nominal 100 mg/L of the test item revealed no toxicity to daphnids. The 48h EC50 was > 100 mg/L (nominal) and, thus, could not be deterrnined in this study.
Key value for chemical safety assessment
Additional information
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