2-Propenenitrile, polymer with 1,2-ethanediamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Justification for type of information:

The substance has low vapour pressure
Although supplied in water and used in liquid form, there is a low risk of aerosol formation during normal use as a corrosion inhibitor in closed systems.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Although done to a recognised screening test method, the nature of this UVCB substance means that only the the most volatile constuent will have been measured; in the case of this reaction product, it is likely that unreacted starting materials may contribute to the findings.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

Dynamic method

GLP compliance:

no

Type of method:

effusion method: isothermal thermogravimetry

Test no.:

#1

Temp.:

ca. 20 °C

Vapour pressure:

ca. 644 Pa

Use of ebulliometer, with the temperature stabilised at 107 C. Calculated back for 20 C

Conclusions:

Although done to a recognised screening test method, the nature of this UVCB substance means that only the the most volatile constuent will have been measured; in the case of this reaction product, it is likely that low molecular weight components will contribute to the findings. However, the smallest identified component has an estimated vapour pressure of < 10 Pa.

Although it was attempted to remove water, the 'dried' sample will have residual residual water and this is th emost likely reason for the higher than expected vapour pressure.

A very large proportion of the components have molecular weights in excess of 200 and a review of vapour pressure data suggests < 0.1 Pa can be expected; however, the same modelling and assessment suggest that the product should be solid (this makes the presence of significant levels of water or liquid amines acting as solvent).

A figure of 644 Pa is considered high for the CSR and a more conservative figure of 1 Pa is used.