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EC number: 942-582-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-07-2017 to 11-09-2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.1 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 2 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.7 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 6 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.5 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 12 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.7 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 24 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 96.9 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 72 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 98.6 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate
- Loading of aqueous phase:
- 100 other: mg/L of test item
- Incubation duration:
- 168 h
- Test conditions:
- - Reconstituted standard based on ISO 6341;
- The aqueous medium solution sterilized by filtration (0.2 µm)
- pH=7;
- 20 +/- 1 °C;
- dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 54.1 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate; Calcium
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 0 h
- Test conditions:
- - Purified water adjusted to pH 2;
- 37 +/- 1°C;
- Dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 98.1 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate; Calcium
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 0.5 h
- Test conditions:
- - Purified water adjusted to pH 2;
- 37 +/- 1°C;
- Dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 99.3 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate; Calcium
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 2 h
- Test conditions:
- - Purified water adjusted to pH 2;
- 37 +/- 1°C;
- Dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.8 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate; Calcium
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 4 h
- Test conditions:
- - Purified water adjusted to pH 2;
- 37 +/- 1°C;
- Dark conditions. - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- ca. 97.5 other: Total recovery (%)
- Element analysed:
- Sodium; Potassium; Sulphate; Calcium
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 6 h
- Test conditions:
- - Purified water adjusted to pH 2;
- 37 +/- 1°C;
- Dark conditions. - Conclusions:
- The transformation/dissolution of the test item in reconstituted standard water based on ISO6341 at pH 7 at 100 mg/L at 20± 1 °C has been determined by ion chromatography. The results demonstrate that the test item is effectively completely transformed/dissolved within 2 hours.
The transformation/dissolution of the test item in purified water adjusted to pH 2 at 10 g/L at 37 °C ± 1 °C has been determined by ion chromatography. The results demonstrate that the test item is effectively completely transformed/dissolved within 30 minutes. - Executive summary:
The transformation/dissolution of the test item has been determined using a GLP-compliant procedure designed to be compatible with Annex 10, Guidance on Transformation/Dissolution of Metals and Metal Compounds in Aqueous Media, OECD Environment, Health and Safety Publications, Series on Testing and Assessment, No.29, Environment Directorate,Organisationfor Economic Co-operation and Development, 23 July 2001.
The results are summarized below:
The transformation/dissolution of the test item in reconstituted standard water based on ISO6341 at pH 7 at 100 mg/L at 20 ± 1 °C has been determined by ion chromatography. The results of the analysis by ion chromatography are shown in the following table:
Shaking time at 20°C (hours)
Sodium
(g/kg)Potassium
(g/kg)Sulphate
(g/kg)Residue
(g/kg)Total recovery (%)
2
67.2
330
574
-
97.1
6
69.8
331
577
-
97.7
12
68.3
331
576
-
97.5
24
70.9
331
575
-
97.7
72
63.6
331
574
-
96.9
168
68.6
340
577
None detected
98.6
The results demonstrate that the test item is effectively completely transformed/dissolved within 2 hours into Na+, K+, SO4-- ions when added in ISO 6341 medium at pH 7 and 20°C (calcium was not analysed because its level in EXP was too low compared to the concentration of calcium in the tested medium).
The transformation/dissolution of the test item in pH 2 purified water at 10 g/L at 37 °C ± 1 °C has been determined by ion chromatography. The results of the analysis by ion chromatography are shown in the following table:
Shaking time at 37°C (hours)
Sodium
(g/kg)Potassium
(g/kg)Calcium
(g/kg)Sulphate (g/kg)
Residue
(g/kg)
Total recovery (%)
0
25.7
179
2.59
334
-
54.1
0.5
52.4
329
3.28
596
-
98.1
2
54.0
332
3.41
603
-
99.3
4
52.9
328
3.29
594
-
97.8
6
52.3
327
3.23
592
4.0
97.4
The results demonstrate that the test item is effectively completely transformed/dissolved within 30 minutes into Na+, K+, Ca++, SO4-- ions when added in purified water at pH 2 and 37°C.
2-RESULTS
2.1-TRANSFORMATION/DISSOLUTION AT PH 7
2.1.1-ION CHROMATOGRAPHY
The mean concentrations (mg/L, corrected for matrix blank), concentration per unit mass (mg/kg) and as a percentage recovery for the sodium, potassium and sulphate analyses are shown in the following tables
Sodium
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
6.9337 |
68043.8 |
6.80 |
SPL 2 2hr |
7.1597 |
65624.8 |
6.56 |
SPL 3 2hr |
6.6097 |
67791.5 |
6.78 |
SPL 1 6hr |
7.3312 |
71944.7 |
7.19 |
SPL 2 6hr |
7.6312 |
69946.5 |
7.00 |
SPL 3 6hr |
6.5822 |
67509.4 |
6.75 |
SPL 1 12hr |
7.2342 |
70992.8 |
7.10 |
SPL 2 12hr |
7.2722 |
66656.0 |
6.67 |
SPL 3 12hr |
6.5552 |
67232.5 |
6.72 |
SPL 1 24hr |
7.2432 |
71081.1 |
7.11 |
SPL 2 24hr |
7.6817 |
70409.4 |
7.04 |
SPL 3 24hr |
6.9537 |
71319.7 |
7.13 |
SPL 1 72hr |
6.8797 |
67513.9 |
6.75 |
SPL 2 72hr |
6.5607 |
60134.4 |
6.01 |
SPL 3 72hr |
6.1462 |
63037.6 |
6.30 |
SPL 1 168hr |
7.6570 |
75142.0 |
7.51 |
SPL 2 168hr |
6.8207 |
62517.6 |
6.25 |
SPL 3 168hr |
6.6382 |
68083.8 |
6.81 |
Potassium
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
33.8808 |
332491 |
33.25 |
SPL 2 2hr |
35.8413 |
328518 |
32.85 |
SPL 3 2hr |
32.0138 |
328347 |
32.83 |
SPL 1 6hr |
34.0973 |
334616 |
33.46 |
SPL 2 6hr |
35.8568 |
328660 |
32.87 |
SPL 3 6hr |
32.1033 |
329265 |
32.93 |
SPL 1 12hr |
34.0898 |
334542 |
33.45 |
SPL 2 12hr |
35.8863 |
328931 |
32.89 |
SPL 3 12hr |
32.0808 |
329034 |
32.90 |
SPL 1 24hr |
34.0133 |
333791 |
33.38 |
SPL 2 24hr |
35.8743 |
328821 |
32.88 |
SPL 3 24hr |
32.1443 |
329686 |
32.97 |
SPL 1 72hr |
34.2493 |
336107 |
33.61 |
SPL 2 72hr |
35.8843 |
328912 |
32.89 |
SPL 3 72hr |
32.0253 |
328465 |
32.85 |
SPL 1 168hr |
36.2023 |
355273 |
35.53 |
SPL 2 168hr |
35.8283 |
328399 |
32.84 |
SPL 3 168hr |
32.7953 |
336362 |
33.64 |
Sulphate
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
58.8786 |
577807 |
57.78 |
SPL 2 2hr |
62.9819 |
577286 |
57.73 |
SPL 3 2hr |
55.2756 |
566929 |
56.69 |
SPL 1 6hr |
59.2475 |
581428 |
58.14 |
SPL 2 6hr |
62.9803 |
577271 |
57.73 |
SPL 3 6hr |
55.6540 |
570811 |
57.08 |
SPL 1 12hr |
59.1072 |
580051 |
58.01 |
SPL 2 12hr |
62.6056 |
573837 |
57.38 |
SPL 3 12hr |
55.9918 |
574275 |
57.43 |
SPL 1 24hr |
58.9411 |
578421 |
57.84 |
SPL 2 24hr |
62.5150 |
573003 |
57.30 |
SPL 3 24hr |
55.7930 |
572236 |
57.22 |
SPL 1 72hr |
59.1190 |
580167 |
58.02 |
SPL 2 72hr |
61.9963 |
568252 |
56.83 |
SPL 3 72hr |
55.9563 |
573911 |
57.39 |
SPL 1 168hr |
59.2752 |
581700 |
58.17 |
SPL 2 168hr |
61.6852 |
565400 |
56.54 |
SPL 3 168hr |
56.9305 |
583903 |
58.39 |
2.1.2-ICP-MS (confirmatory analysis)
From the analysis of the sample solutions, the counts per second for each analyte were interpolated from the respective calibrations to give the concentration of analyte (mg/L). The mean concentrations (mg/L), concentration per unit mass (mg/kg) and as a percentage recovery for the sodium, potassium and sulphate analyses are shown in the following tables:
Sodium
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
7.17 |
70345 |
7.03 |
SPL 2 2hr |
8.59 |
78709 |
7.87 |
SPL 3 2hr |
7.44 |
76328 |
7.63 |
SPL 1 6hr |
8.24 |
80848 |
8.08 |
SPL 2 6hr |
7.44 |
68186 |
6.82 |
SPL 3 6hr |
7.41 |
75967 |
7.60 |
SPL 1 12hr |
7.78 |
76379 |
7.64 |
SPL 2 12hr |
7.65 |
70107 |
7.01 |
SPL 3 12hr |
9.11 |
93424 |
9.34 |
SPL 1 24hr |
8.36 |
82054 |
8.21 |
SPL 2 24hr |
9.12 |
83582 |
8.36 |
SPL 3 24hr |
8.47 |
86842 |
8.68 |
SPL 1 72hr |
10.2 |
100362 |
10.0 |
SPL 2 72hr |
8.87 |
81275 |
8.13 |
SPL 3 72hr |
8.39 |
86031 |
8.60 |
SPL 1 168hr |
10.1 |
99181 |
9.92 |
SPL 2 168hr |
8.53 |
78216 |
7.82 |
SPL 3 168hr |
8.08 |
82886 |
8.29 |
Potassium
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
37.2 |
364925 |
36.5 |
SPL 2 2hr |
32.4 |
297010 |
29.7 |
SPL 3 2hr |
30.8 |
315478 |
31.6 |
SPL 1 6hr |
32.1 |
314940 |
31.5 |
SPL 2 6hr |
34.1 |
312152 |
31.2 |
SPL 3 6hr |
29.8 |
305441 |
30.5 |
SPL 1 12hr |
31.7 |
310825 |
31.1 |
SPL 2 12hr |
34.3 |
314660 |
31.5 |
SPL 3 12hr |
30.3 |
310682 |
31.1 |
SPL 1 24hr |
34.3 |
336110 |
33.6 |
SPL 2 24hr |
35.3 |
324221 |
32.4 |
SPL 3 24hr |
31.4 |
321639 |
32.2 |
SPL 1 72hr |
34.6 |
339226 |
33.9 |
SPL 2 72hr |
35.5 |
325232 |
32.5 |
SPL 3 72hr |
32.5 |
333472 |
33.4 |
SPL 1 168hr |
34.9 |
342158 |
34.2 |
SPL 2 168hr |
34.8 |
318893 |
31.9 |
SPL 3 168hr |
31.6 |
323864 |
32.4 |
Sulphate
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 2hr |
52.0 |
509811 |
51.0 |
SPL 2 2hr |
57.1 |
523100 |
52.3 |
SPL 3 2hr |
52.2 |
535301 |
53.5 |
SPL 1 6hr |
56.7 |
556379 |
55.6 |
SPL 2 6hr |
61.3 |
561922 |
56.2 |
SPL 3 6hr |
46.0 |
471789 |
47.2 |
SPL 1 12hr |
50.4 |
495081 |
49.5 |
SPL 2 12hr |
59.0 |
541034 |
54.1 |
SPL 3 12hr |
47.7 |
488835 |
48.9 |
SPL 1 24hr |
51.7 |
507445 |
50.7 |
SPL 2 24hr |
61.1 |
559708 |
56.0 |
SPL 3 24hr |
52.6 |
539425 |
53.9 |
SPL 1 72hr |
55.6 |
545592 |
54.6 |
SPL 2 72hr |
64.2 |
588460 |
58.9 |
SPL 3 72hr |
49.8 |
511104 |
51.1 |
SPL 1 168hr |
55.6 |
545856 |
54.6 |
SPL 2 168hr |
61.0 |
559220 |
55.9 |
SPL 3 168hr |
50.7 |
519631 |
52.0 |
2.1.3-DISCUSSION
The definitive results obtained by ion chromatography were assessed for reproducibility from the triplicate flasks for all time points. This demonstrated mean relative standard deviation of 4.06% for sodium, 1.50% for potassium, 0.99% forsulphate and therefore the test was considered to be consistent across the flasks at all the time points.
Comparison of the results obtained in the test with the theoretical concentrations from the Certificate of Analysis (sodium 66.0 g/kg, potassium 313 g/kg,sulphate564 g/kg), demonstrates that the test item was essentially fully dissolved in the test media at all time points.
The pH of the test solutions was stable (<0.2 pH unit deviation) over the duration of the study.
The dissolved oxygen level in all the test solutions was greater than 70% saturation (6.0 mg/L) and thus satisfied the guideline.
The calcium content of the solutions was not determined since there was a significant amount of calcium present in the test medium, and therefore it was considered that it would not be possible to obtain reliable results.
The ICP-MS confirmatory analysis demonstrated no significant difference in the levels of sodium, potassium andsulphate in the samples solutions.
The study results reported from the ion chromatography analysis were considered acceptable.
2.2-TRANSFORMATION/DISSOLUTION AT PH 2
2.2.1-ION CHROMATOGRAPHY
Sodium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
0.236 |
2.31 x 104 |
2.31 |
SPL 2 0hr |
0.276 |
2.65 x 104 |
2.66 |
SPL 3 0hr |
0.285 |
2.75 x 104 |
2.75 |
SPL 1 0.5hr |
0.537 |
5.26 x 104 |
5.26 |
SPL 2 0.5hr |
0.546 |
5.26 x 104 |
5.26 |
SPL 3 0.5hr |
0.537 |
5.19 x 104 |
5.19 |
SPL 1 2hr |
0.590 |
5.78 x 104 |
5.78 |
SPL 2 2hr |
0.534 |
5.14 x 104 |
5.14 |
SPL 3 2hr |
0.547 |
5.29 x 104 |
5.29 |
SPL 1 4hr |
0.528 |
5.18 x 104 |
5.18 |
SPL 2 4hr |
0.550 |
5.30 x 104 |
5.30 |
SPL 3 4hr |
0.559 |
5.40 x 104 |
5.40 |
SPL 1 6hr |
0.541 |
5.30 x 104 |
5.30 |
SPL 2 6hr |
0.535 |
5.15 x 104 |
5.15 |
SPL 3 6hr |
0.541 |
5.23 x 104 |
5.23 |
Potassium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
1.69 |
1.66 x 105 |
16.6 |
SPL 2 0hr |
1.97 |
1.90 x 105 |
19.0 |
SPL 3 0hr |
1.88 |
1.81 x 105 |
18.1 |
SPL 1 0.5hr |
3.36 |
3.29 x 105 |
32.9 |
SPL 2 0.5hr |
3.42 |
3.30 x 105 |
33.0 |
SPL 3 0.5hr |
3.40 |
3.29 x 105 |
32.9 |
SPL 1 2hr |
3.48 |
3.41 x 105 |
34.1 |
SPL 2 2hr |
3.40 |
3.28 x 105 |
32.8 |
SPL 3 2hr |
3.40 |
3.28 x 105 |
32.8 |
SPL 1 4hr |
3.34 |
3.27 x 105 |
32.7 |
SPL 2 4hr |
3.42 |
3.29 x 105 |
32.9 |
SPL 3 4hr |
3.38 |
3.27 x 105 |
32.7 |
SPL 1 6hr |
3.33 |
3.26 x 105 |
32.6 |
SPL 2 6hr |
3.43 |
3.30 x 105 |
33.0 |
SPL 3 6hr |
3.36 |
3.25 x 105 |
32.5 |
Calcium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
2.60 x 10-2 |
2.55 x 103 |
0.255 |
SPL 2 0hr |
2.37 x 10-2 |
2.28 x 103 |
0.228 |
SPL 3 0hr |
3.04 x 10-2 |
2.94 x 103 |
0.294 |
SPL 1 0.5hr |
3.47 x 10-2 |
3.40 x 103 |
0.340 |
SPL 2 0.5hr |
3.41 x 10-2 |
3.29 x 103 |
0.329 |
SPL 3 0.5hr |
3.24 x 10-2 |
3.14 x 103 |
0.314 |
SPL 1 2hr |
3.71 x 10-2 |
3.64 x 103 |
0.364 |
SPL 2 2hr |
3.49 x 10-2 |
3.36 x 103 |
0.336 |
SPL 3 2hr |
3.33 x 10-2 |
3.22 x 103 |
0.322 |
SPL 1 4hr |
3.32 x 10-2 |
3.25 x 103 |
0.325 |
SPL 2 4hr |
3.48 x 10-2 |
3.35 x 103 |
0.335 |
SPL 3 4hr |
3.37 x 10-2 |
3.25 x 103 |
0.325 |
SPL 1 6hr |
3.08 x 10-2 |
3.01 x 103 |
0.301 |
SPL 2 6hr |
3.44 x 10-2 |
3.32 x 103 |
0.332 |
SPL 3 6hr |
3.47 x 10-2 |
3.35 x 103 |
0.335 |
Sulphate
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
3.18 |
3.11 x 105 |
31.1 |
SPL 2 0hr |
3.65 |
3.52 x 105 |
35.2 |
SPL 3 0hr |
3.51 |
3.39 x 105 |
33.9 |
SPL 1 0.5hr |
6.08 |
5.96 x 105 |
59.6 |
SPL 2 0.5hr |
6.20 |
5.97 x 105 |
59.7 |
SPL 3 0.5hr |
6.15 |
5.95 x 105 |
59.5 |
SPL 1 2hr |
6.31 |
6.18 x 105 |
61.8 |
SPL 2 2hr |
6.19 |
5.96 x 105 |
59.6 |
SPL 3 2hr |
6.16 |
5.95 x 105 |
59.5 |
SPL 1 4hr |
6.05 |
5.93 x 105 |
59.3 |
SPL 2 4hr |
6.19 |
5.96 x 105 |
59.6 |
SPL 3 4hr |
6.14 |
5.94 x 105 |
59.4 |
SPL 1 6hr |
6.04 |
5.92 x 105 |
59.2 |
SPL 2 6hr |
6.16 |
5.93 x 105 |
59.3 |
SPL 3 6hr |
6.11 |
5.91 x 105 |
59.1 |
2.2.2-ICP-MS (confirmatory analysis)
From the analysis of the sample solutions, the counts per second for each analyte were interpolated from the respective calibrations to give the concentration of analyte (mg/L). The mean concentrations (g/L), concentration per unit mass (mg/kg) and percentage recovery for the sodium, potassium, calcium and sulphate analyses are shown in the following tables:
Sodium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
0.401 |
3.93 x 104 |
3.93 |
SPL 2 0hr |
0.547 |
5.27 x 104 |
5.27 |
SPL 3 0hr |
0.369 |
3.56 x 104 |
3.56 |
SPL 1 0.5hr |
0.596 |
5.84 x 104 |
5.84 |
SPL 2 0.5hr |
1.04 |
1.00 x 105 |
10.0 |
SPL 3 0.5hr |
0.917 |
8.87 x 104 |
8.87 |
SPL 1 2hr |
0.707 |
6.92 x 104 |
6.92 |
SPL 2 2hr |
1.01 |
9.78 x 104 |
9.78 |
SPL 3 2hr |
0.971 |
9.39 x 104 |
9.39 |
SPL 1 4hr |
0.663 |
6.50 x 104 |
6.50 |
SPL 2 4hr |
1.11 |
1.07 x 105 |
10.7 |
SPL 3 4hr |
0.844 |
8.16 x 104 |
8.16 |
SPL 1 6hr |
0.721 |
7.07 x 104 |
7.07 |
SPL 2 6hr |
1.06 |
1.02 x 105 |
10.2 |
SPL 3 6hr |
0.963 |
9.31 x 104 |
9.31 |
Potassium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
2.10 |
2.06 x 105 |
20.6 |
SPL 2 0hr |
2.73 |
2.63 x 105 |
26.3 |
SPL 3 0hr |
2.70 |
2.61 x 105 |
26.1 |
SPL 1 0.5hr |
3.75 |
3.67 x 105 |
36.7 |
SPL 2 0.5hr |
4.82 |
4.64 x 105 |
46.4 |
SPL 3 0.5hr |
4.89 |
4.73 x 105 |
47.3 |
SPL 1 2hr |
3.82 |
3.75 x 105 |
37.5 |
SPL 2 2hr |
4.57 |
4.40 x 105 |
44.0 |
SPL 3 2hr |
4.93 |
4.77 x 105 |
47.7 |
SPL 1 4hr |
3.77 |
3.70 x 105 |
37.0 |
SPL 2 4hr |
5.24 |
5.05 x 105 |
50.5 |
SPL 3 4hr |
5.02 |
4.85 x 105 |
48.5 |
SPL 1 6hr |
3.94 |
3.86 x 105 |
38.6 |
SPL 2 6hr |
4.72 |
4.55 x 105 |
45.5 |
SPL 3 6hr |
4.99 |
4.82 x 105 |
48.2 |
Calcium
Sample |
Meanconcentration (g/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
2.51 x 10-2 |
2.46 x 103 |
0.246 |
SPL 2 0hr |
2.44 x 10-2 |
2.35 x 103 |
0.235 |
SPL 3 0hr |
2.48 x 10-2 |
2.40 x 103 |
0.240 |
SPL 1 0.5hr |
3.28 x 10-2 |
3.22 x 103 |
0.322 |
SPL 2 0.5hr |
4.07 x 10-2 |
3.93 x 103 |
0.393 |
SPL 3 0.5hr |
3.61 x 10-2 |
3.49 x 103 |
0.349 |
SPL 1 2hr |
3.63 x 10-2 |
3.56 x 103 |
0.356 |
SPL 2 2hr |
3.90 x 10-2 |
3.76 x 103 |
0.376 |
SPL 3 2hr |
3.47 x 10-2 |
3.35 x 103 |
0.335 |
SPL 1 4hr |
3.31 x 10-2 |
3.25 x 103 |
0.325 |
SPL 2 4hr |
3.73 x 10-2 |
3.60 x 103 |
0.360 |
SPL 3 4hr |
3.10 x 10-2 |
3.00 x 103 |
0.300 |
SPL 1 6hr |
3.48 x 10-2 |
3.41 x 103 |
0.341 |
SPL 2 6hr |
4.24 x 10-2 |
4.09 x 103 |
0.409 |
SPL 3 6hr |
3.51 x 10-2 |
3.39 x 103 |
0.339 |
Sulphate
Sample |
Meanconcentration (mg/L) |
Meanconcentration (mg/kg) |
Recovery (%) |
SPL 1 0hr |
2.60 x 103 |
2.55 x 105 |
25.5 |
SPL 2 0hr |
3.34 x 103 |
3.27 x 105 |
32.7 |
SPL 3 0hr |
3.40 x 103 |
3.33 x 105 |
33.3 |
SPL 1 0.5hr |
4.68 x 103 |
4.58 x 105 |
45.8 |
SPL 2 0.5hr |
5.58 x 103 |
5.47 x 105 |
54.7 |
SPL 3 0.5hr |
5.46 x 103 |
5.35 x 105 |
53.5 |
SPL 1 2hr |
4.52 x 103 |
4.42 x 105 |
44.2 |
SPL 2 2hr |
5.65 x 103 |
5.54 x 105 |
55.4 |
SPL 3 2hr |
5.66 x 103 |
5.55 x 105 |
55.5 |
SPL 1 4hr |
4.65 x 103 |
4.56 x 105 |
45.6 |
SPL 2 4hr |
5.44 x 103 |
5.33 x 105 |
53.3 |
SPL 3 4hr |
5.47 x 103 |
5.36 x 105 |
53.6 |
SPL 1 6hr |
4.57 x 103 |
4.48 x 105 |
44.8 |
SPL 2 6hr |
5.76 x 103 |
5.64 x 105 |
56.4 |
SPL 3 6hr |
6.16 x 103 |
6.04 x 105 |
60.4 |
2.2.3-DISCUSSION
The definitive results obtained by ion chromatography were assessed for reproducibility from the triplicate flasks for all time points. This demonstrated mean relative standard deviations of 3.89% for sodium, 2.07% for potassium, 6.13% for calcium and 1.80% for sulphate. Sodium, potassium and sulphate analysis were considered to be consistent (<5% RSD) across the flasks at all the time points. The higher variability in the calcium results was considered to be due to lower concentrations present in the sample solutions.
Comparison of the results obtained in the test with the theoretical concentrations from the Certificate of Analysis (sodium 66.0 g/kg, potassium 313 g/kg, sulphate 564 g/kg, calcium 0.285 g/kg), demonstrates that the test item was essentially fully dissolved in the test media after 30 minutes.
Although the ICP-MS confirmatory analysis demonstrated minor differences in reported concentrations, the analysis served to confirm the analyte species and approximate levels in the sample solutions.
For the analysis by IC, matrix blanks were demonstrated generally low and inconsistent peak areas, therefore it was not considered necessary to correct the sample results for the contribution from the matrix blanks. In the ICP-MS analysis, matrix blanks were significant for sulphur(sulphate analysis) and therefore matrix blank corrections were applied to all ICP-MS analysis.
At each time point from 0.5 hour onwards, all of the samples were observed to be clear colorless and free from excess undissolved test item.
The pH of all the test solutions increased after addition of test item to pH 2.3 and remained stable throughout the duration of the test.
The dissolved oxygen level in all the test solutions was greater than 70% saturation (6.0 mg/L) and thus satisfied the guideline.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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