Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-132-3 | CAS number: 78-67-1
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Cifkova, I. et al.: Ceskoslov. Farm. 37 (8), 268-371 (1988)
Materials and methods
- Principles of method if other than guideline:
- The aim of the study was to investigate the effect of mixtures (including the test substance) extracted from poly(HEMA)-gels on the tissue reactions when applied intradermally or implanted into an experimental organism. The tissue reaction was determined by measuring 113In.
Test material
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- TS-Freetext:
2,2'-azobisisobutyronitrile; no data on purity of the
compound
Constituent 1
Administration / exposure
- Route of administration:
- other: intradermal or implantation
Results and discussion
- Details on results:
- When using the implant technique, the rapidity of diffusion of the test substance from the implant was found to be rather slow; the concentration of the test substance in its surroundings did not reach the threshold value to produce a pertinent tissue reaction. Similar results were obtained after intradermal application of the test substance.
Any other information on results incl. tables
The aim of the study was to investigate the effect of mixtures (including the test substance) extracted from poly(HEMA)-gels on the tissue reactions when applied intradermally or implanted into an experimental organism. The tissue reaction was determined by measuring 113In. When using the implant technique, the rapidity of diffusion of the test substance from the implant was found to be rather slow; the concentration of the test substance in its surroundings did not reach the threshold value to produce a pertinent tissue reaction. Similar results were obtained after intradermal application of the test substance. Csechoslovakian publication with English, German and Russian abstract.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
