Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- June 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
- Author:
- Unknown
- Year:
- 2 005
- Bibliographic source:
- Journal of the American College of Toxicology
Materials and methods
Test guideline
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Remarks:
- information not available
Test material
- Reference substance name:
- Myristic acid
- EC Number:
- 208-875-2
- EC Name:
- Myristic acid
- Cas Number:
- 544-63-8
- Molecular formula:
- C14H28O2
- IUPAC Name:
- Tetradecanoic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Commercial grade myristic acid
Test animals
- Species:
- other: human
Test system
- Type of coverage:
- occlusive
- Number of animals:
- 20
- Details on study design:
- SIOPT (single insult occlusive patch test)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: primary irritation index
- Score:
- 0.2
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Commercial grade myristic acid produced no irritation in 17, mild erythema in 2, and moderate erythema in 1 of 20 panelists.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The primary irritation index was 0.2, and myristic acid was considered "practically non irritating."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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