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EC number: 472-110-0 | CAS number: 71868-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Sep - 14 Oct 2004 (experimental period)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 472-110-0
- EC Name:
- -
- Cas Number:
- 71868-15-0
- Molecular formula:
- C20H22O5
- IUPAC Name:
- 2-hydroxy-1-{4-[4-(2-hydroxy-2-methylpropanoyl)phenoxy]phenyl}-2-methylpropan-1-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratoires, L'Arbresle Cedex, France.
- Females nulliparous and non-pregnant: yes .
- Age at study initiation: 8-12 weeks at the time of administration.
- Weight at study initiation: Within ± 20% of the mean weight of any previously dosed animals.
- Fasting period before study: yes, deprived of food since the previous day.
- Housing: Daily observations were performed at the time of delivery of the animals and during the period of acclimatization. Animals were housed in cages of standard dimensions with sawdust bedding (or equivalent). Cages were cleaned at least once per week. The animals were placed in an air-conditioned (19-23°C) animal house kept at relative humidity between 45% and 65% in which non-recycled filtered air was changed approximately 10 times per hour. The artificial day/night cycle involved 12 hours light and 12 hours darkness with light on at 7.30 a.m.
- Diet (e.g. ad libitum): RM1 (E)-SQC SDS/DIETEX feed (quality controlled/radiation sterilised) was available ad libitum (except during the fasting experimental period). The criteria for acceptable levels of contaminants in the feed supply were within the limits of the analytical specifications established by the diet manufacturer.
- Water (e.g. ad libitum): Drinking water was available ad libitum in polycarbonate feeder bottles with a stainless steel nipple. A specimen of water is obtained every 6 months and sent to a laboratory for analysis. The criteria for acceptable levels of contaminants in the water supply were within the limits of the analytical specifications.
- Acclimation period: Minimum of five days before treatment in the laboratory animal house where the experiment took place.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - Vehicle: sterile water
- dose volume applied: 10mL/kg - Doses:
- 2000 mg/kg bw (limit test; at request of the sponsor)
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
Results and discussion
- Preliminary study:
- -
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no 95% CL stated
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No clinical signs were observed from D1 to D14 during the course of the first step of the study. On D1 (about 3 hours 30 minutes post-dosing), all females presented a piloerection during the second step of the study. No clinical signs were observed from D
- Gross pathology:
- No organ or tissue gross findings were seen at necropsy
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- other: EU-GHS criteria not met
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance in female SD rats according to OECD Guideline 423, in compliance with GLP. At the first step, a group of three females was treated with the starting dose of 2000 mg/kg bw, followed by an additional group of three animals at the same dose level. The test substance was administered orally to animals deprived of food since the previous day, in a volume of 10 mL/kg as a white homogeneous suspension in sterile water. The rats were monitored daily for 14 days after administration of the test substance. Bodyweight was recorded on Days 1, 7, 14 and 15. No mortality occurred during the study. No clinical signs were observed from Day 1 to 14 in the first step of the study. On Day 1 (about 3.5 h post-dosing), all females presented piloerection during the second step of the study. No further clinical signs were recorded. Mean bodyweight gain in treated animals was within the expected normal range. No organ or tissue gross findings were seen at necropsy. Under the study conditions, the acute oral LD50 of the test substance in rats was greater than 2000 mg/kg bw (Baudet, 2004).
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