Registration Dossier
Registration Dossier
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EC number: 211-949-7 | CAS number: 719-59-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-amino-5-chlorobenzophenone
- EC Number:
- 211-949-7
- EC Name:
- 2-amino-5-chlorobenzophenone
- Cas Number:
- 719-59-5
- Molecular formula:
- C13H10ClNO
- IUPAC Name:
- (2-amino-5-chlorophenyl)(phenyl)methanone
- Test material form:
- solid: particulate/powder
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 16 mg of pure substance
- Duration of treatment / exposure:
- 42 min
- Number of replicates:
- 3
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- Mean
- Value:
- 102.2
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The skin irritation potential was determined according to OECD 439 guideline on reconstructed human epidermis. The study shows a mean viability percent of 102.2%. Th test item is not considered as irritant for skin.
- Executive summary:
The skin irritation potential was determined according to OECD 439 guideline on reconstructed human epidermis. The study shows a mean viability percent of 102.2%. Th test item is not considered as irritant for skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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