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EC number: 309-363-2 | CAS number: 100231-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation in vivo (OECD 406, Buehler): not sensitising
Read-across from structural analogue source substance D-Glucopyranose, oligomers, hexyl glycosides (CAS 54549-24-5)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue justification report provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 75%
- No. with + reactions:
- 0
- Total no. in group:
- 9
- Clinical observations:
- One animal was found dead on Day 22.
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 75%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 75%
- No. with + reactions:
- 0
- Total no. in group:
- 9
- Clinical observations:
- One animal was found dead on Day 22.
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 75%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 9
- Clinical observations:
- One animal was found dead on Day 22.
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 9
- Clinical observations:
- One animal was found dead on Day 22.
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Source, 54549-24-5, Safepharm Laboratories, 1998a
- Key result
- Group:
- positive control
- Remarks on result:
- other: summary of historical positive control data appended to study report
- Remarks:
- Source, 54549-24-5, Safepharm Laboratories, 1998
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- Based on the results of a Buehler test conducted with a structurally analogue substance, the target substance is not expected to be a skin sensitiser.
- Executive summary:
The skin sensitisation potential of the target substance is estimated based on an adequate and reliable in vivo study from a structural analogue source substance. In the study following the Buehler test design, no skin sensitisation was observed following occlusive epicutaneous challenge after induction treatments (occlusive epicutaneous exposure). Therefore, based on read-across, for the target substance no hazard regarding skin sensitisation is expected.. As explained in the analogue justification, the differences in molecular structure between the target and the source substance are unlikely to lead to differences in the skin sensitisation potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on the results of a Buehler test conducted with a structurally analogue substance, D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) is not expected to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation from an adequate analogue substance do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP). Data are, therefore, conclusive but not sufficient for classification. Based on read-across, D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) is also considered not to meet the criteria for classification for skin sensitisation. No data regarding respiratory sensitisation are available.
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