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EC number: 271-571-3 | CAS number: 68585-64-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 - 25 May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
- Remarks:
- The study was conducted in full compliance with GLP guidelines with one exception. For more details please refer to field "Any other Information on Material and Methods incl. tables".
Test material
- Reference substance name:
- Dihydrogen bis[P,P-dioctyl diphosphato(2-)-O'',O''''][hydroxyacetato(2-)-O1,O2]titanate(2-), branched and linear
- EC Number:
- 271-571-3
- EC Name:
- Dihydrogen bis[P,P-dioctyl diphosphato(2-)-O'',O''''][hydroxyacetato(2-)-O1,O2]titanate(2-), branched and linear
- Cas Number:
- 68585-64-8
- Molecular formula:
- not applicable (UVCB substance)
- IUPAC Name:
- ({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)[(2-{[({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)(hydroxy)phosphoryl]oxy}-4-oxo-1,3-dioxa-2-titanacyclopentan-2-yl)oxy]phosphinic acid; {[({bis[(2-ethylhexyl)oxy]phosphanyl}oxy)({[({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)(hydroxy)phosphoryl]oxy})[(2-hydroxyacetyl)oxy]titanio]oxy}({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)phosphinic acid
1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- LC-MS/MS
- Details on sampling:
- - Loading rates: control, 1, 10, 100 mg/L
- Sampling method: Samples were collected from fresh parent test solution samples at 0 h (initiation) and from a composite of spent replicate solutions at 48 h (termination) of the test. At each sampling point, a 5 mL sample was collected from the control and each test substance treatment.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The 1.00, 10.0, and 100 mg/L test item solutions were prepared as water accommodated fractions (WAF) by weighing 0.00200, 0.0200, and 0.200 g, of the substance respectively, into glass carboys containing 2 L of dilution water (freshwater). Solutions were covered with Parafilm® sealing film and stirred on an electric stir plate for approx. 22 h at room temperature, with the stirring adjusted to provide a vortex ≤25% of the solution depth. The solutions were then allowed to settle for approx. 4 h.The test treatment collections were conducted by drawing the appropriate amount of test solutions through a glass siphon tube held approximately one inch from the bottom of each glass carboy. Prior to dispensing test treatment collections, approximately 100 mL of each test solution was drained through the syphon tube and discarded.
- Differential loading: yes
- Controls: The control solution contained dilution water without test item.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Age of parental stock (mean and range, SD): < 24 h
- Feeding during test: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 150 mg CaCO3/L
- Test temperature:
- 20 ± 1°C
- pH:
- 7.7 to 8.6
- Dissolved oxygen:
- 7.6 to 8.5 mg/L (90 to 98% saturation)
- Conductivity:
- 349 μS/cm
- Nominal and measured concentrations:
- Nominal Loading Rates: 0 (control), 1, 10, and 100 mg/L
Geom. Mean Measured concentrations:- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250-mL glass jars
- Fill volume: 200 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Blended freshwater
- Alkalinity: 170 mg CaCO3/L
- Culture medium different from test medium: not specified
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/ 8 h dark (30 min transition period)
- Light intensity: 584 to 688 lux
EFFECT PARAMETERS MEASURED: Mobility and sublethal effects at 24 and 48 h.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Mortality of control: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: The control and all test solutions appeared clear and colorless with no visible particulates, surface film, or precipitate throughout the test.
- Effect concentrations exceeding solubility of substance in test medium: no
Any other information on results incl. tables
BIOLOGICAL RESULTS
After 48 h of exposure, there were no mortalities in the control replicates and there were no mortalities observed in any test treatment replicates up to the highest nominal concentration of 100 mg/L. Neither were sublethal effects observed at any dose during the duration of the test exposures.
ANALYTICAL RESULTS
Table 1: Measured Concentrations of Diethylhexyl Phosphite, an Analytical Marker of the UVCB substance, during the 48-h Acute Toxicity Test with Daphnia magna.
Nominal Loading Rate Concentratiomn [mg/L] |
Measured Concentration as mg/L | ||
0 h | 48 h | Geometric Mean Measured Concentration* |
|
control | <MQL | <MQL | <MQL |
1 | 0.0015 | <MQL | 0.00067 |
10 | 0.00447 | <MQL | 0.00116 |
100 | 0.306 | 0.0393 | 0.11 |
* For calculations, ½ MQL (0.000300 mg/L) used where the measured concentration was <MQL.
VALIDITY CRITERIA
Table 2: Validity criteria for OECD 202.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
In the control, including the control containing the solubilising agent, not more than 10% of the daphnids should have been immobilized. |
0% |
yes |
The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in control and test vessels. |
7.6 to 8.5 mg/L throughout the test |
yes |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
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