N-phenyl-N'-[(phenylamino)sulfonyl]urea

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

1-phenyl-3-(phenylsulfamoyl)urea

EC Number:

813-358-5

Cas Number:

4886-26-4

Molecular formula:

C13H13N3O3S

IUPAC Name:

1-phenyl-3-(phenylsulfamoyl)urea

Test material form:

solid: particulate/powder

Results and discussion

Water solubility

Key result

Water solubility:

51.85 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 3.46 - <= 3.58

Applicant's summary and conclusion

Conclusions:

At the plateau, the concentration of N-Phenyl-N'-[phenylamino)sulfonyl]urea in water had reached 51.85 ± 0.37 mg/L at 20.0 ± 0.5 °C

Executive summary:

The solubility of the test itemN-Phenyl-N'-[phenylamino)sulfonyl]urea in water was determined by measurement of the test item concentration in the filtrated test solutions using HPLC.

The preliminary test which is described in the guideline was not performed as the solubility of the test item was estimated during validation of the analytical method as 64.46 ± 0.35 mg/L (measured in a solution with a nominal concentration of 15 g test item/L).

According to the guideline, the flask method was used for the determination of the solubility of the test item in water.

In the main test,one loading rate of the test item was chosen: 1000 mg/L (nominal). Three flasks 1A - C were used during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature (20.0 ± 0.5 °C). Then, flasks 1A - 1C were taken from the shaker, samples were taken, membrane filtered and analysed via HPLC. No rising tendency in the test item concentration of the solutions was found on day 3. Therefore, the plateau of the test item solubility had been reached.

No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles were present.

 

At the plateau, the concentration ofN-Phenyl-N'-[phenylamino)sulfonyl]ureain water had reached

 

51.85 ± 0.37 mg/L at 20.0 ± 0.5 °C

= 5.185 ± 0.037 * 10^-5kg/m³(SI units)

(mean value ± standard deviation of five individual vessels)