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Diss Factsheets
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EC number: 237-857-7 | CAS number: 14024-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- 2,4-Pentanedione. CAS N°: 123-54-6
- Author:
- OECD Organisation for Economic Co-operation and Development
- Year:
- 2 001
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 13 (Paris, France, in June) United Nations Environment Programme (UNEP) Publications, Nairobi, Kenya. 82 p. URL https://hpvchemicals.oecd.org/ui/handler.axd?id=AF8877C9-8DFB-45E0-8188-492EBA68CDAE
- Reference Type:
- publication
- Title:
- 2,4- Pentanedione: 9-Day and 14-Week Vapor Inhalation Studies in Fischer-344 Rats.
- Author:
- Dodd DE, Garman RH, Pritts IM, Troup CM, Snellings WM, Ballantyne B
- Year:
- 1 986
- Bibliographic source:
- Fundamental and Applied Toxicology 7: 329-339
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- Principles of method if other than guideline:
- -Subchronic Inhalation Study in Fischer 344 Male and Female Rats
-Concentrations tested: 0, 100, 300 and 650 ppm
-Pathological observations: testicles, epididymis in males and uteri, cervix and ovaries in females - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Details on species / strain selection:
- TEST ANIMALS
- Source:
Charles River Breeding Laboratories, Inc. (Kingston, NY, USA).
- Age at study initiation:
34 days
- Housing:
2 animals per cage
- Diet :
ad libitum
- Water :
ad libitum
- Acclimation period:
18 days
DETAILS OF FOOD AND WATER QUALITY:
ENVIRONMENTAL CONDITIONS
- Temperature :
65-80 °F
- Humidity (%):
13-84%
- Air changes (per hr):
approx. 14
- Photoperiod (hrs dark / hrs light):
12/12 - Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- whole body
- Remarks on MMAD:
- MMAD and GSD not available
- Vehicle:
- air
- Details on exposure:
- Liquid 2,4-pentanedione was assayed from a piston pump in a heated glass evaporator. The temperature in the evaporator was kept at the lowest level sufficient to vaporize the liquid. The resulting vapor was transported into the chamber by a countercurrent stream of air which entered the bottom of the evaporator.
- Details on mating procedure:
- not available
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The 2,4-pentanedione concentrations in the test chambers were analyzed approximately 2 times per hour (every 33 minutes during the 6 hours of daily exposure) during the 68 days of gas chromatographic testing. Concentration averages were 650 (± 19.3), 307 (± 10.3) and 101 (± 3.5) ppm for target concentrations.
- Duration of treatment / exposure:
- 14 weeks of exposure, followed by a 4 weeks recovery time.
- Frequency of treatment:
- Treatment for 6 hours, 5 hours a day.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm (nominal)
- Dose / conc.:
- 100 ppm (nominal)
- Remarks:
- Corresponding to 417mg/m3 of 2,4-Pentanedione vapour.
- Dose / conc.:
- 300 ppm (nominal)
- Remarks:
- Corresponding to 1217mg/m3 of 2,4-Pentanedione vapour.
- Dose / conc.:
- 650 ppm (nominal)
- Remarks:
- Corresponding to 2711 mg/m3 of 2,4-Pentanedione vapour.
- No. of animals per sex per dose:
- 20 males and 20 females
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- 20 male and 20 female rats per group, half sacrificed at the end of the exposure period and the remainder after a 4-week recovery period for determining the reversibility of observable effects, exposed to nominal concentrations of 0 , 100, 300 and 650 ppm of test substance, respectively. Ten male rats were added to control and high dose groups for glutaraldehyde infusion and subsequent ultrastructural examination of sciatic nerves.
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- not examined
- Dermal irritation (if dermal study):
- not examined
- Mortality:
- not examined
- Body weight and weight changes:
- not examined
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- not examined
Effect levels (P0)
open allclose all
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 417 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: general effects
- Dose descriptor:
- LOAEC
- Effect level:
- ca. 2 711 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: general effects
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 144 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: general effects
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 936.7 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: general effects
Target system / organ toxicity (P0)
- Critical effects observed:
- no
Results: F1 generation
Effect levels (F1)
- Remarks on result:
- not measured/tested
Results: F2 generation
Effect levels (F2)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- The organic part of the substance to be registered does not show any negative effects on the reproductive organs of male and female rats.
- Executive summary:
In a subchronic inhalation study in male and female F344 rats exposed to 0, 100, 300 and 650 ppm (nominal concentrations, corresponding to 0, 417, 1217 and 2711 mg / m3), no evidence of pathological effects were observed in the testes and epididymis of males as well as in the uterus, cervix and ovaries of females compared with untreated control animals immediately after the end of the study and after a period 4-week recovery, respectively, thus revealing no negative effects on the reproductive organs of male and female rats. A NOAEC of 417mg/m3 air was established for the test substance. A NOAEL of 144.1 mg/kg bw/day was then calculated.
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