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EC number: 251-964-6 | CAS number: 34364-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The age and individual body weight of the animals were not stated. Additionally, no information about the environmental conditions was available. No details about the administration of doses and applied amount of test material were given and the test material was not sufficiently described. No justification for dose selection was available.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 2017-10-09
- GLP compliance:
- yes
- Remarks:
- certificate not included
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Bismuth(3+) neodecanoate
- EC Number:
- 251-964-6
- EC Name:
- Bismuth(3+) neodecanoate
- Cas Number:
- 34364-26-6
- Molecular formula:
- C10H19O2.xBi
- IUPAC Name:
- tris[(3,3,5,5-tetramethylhexanoyl)oxy]bismuthine
- Details on test material:
- - Density: 1.13- 1.14 mg/ml
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: New York State Rabbit Development, Hartwick, NY
- Housing: the animals were individually housed in wire mesh bottom cages in environment-controlled rooms
- Diet (e.g. ad libitum): NIH Animal Feed A (certified)
- Water (e.g. ad libitum): yes
- Acclimation period: a minimum of 5 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: occlusive binder, that consisted of a layer of plastic wrap and stockinette sleeve, held in place with masking tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the exposure sites were gently wiped with clean gauze to remove as much non-absorbed test article as possible
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 2.0 g/kg bw
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: all animals were observed frequently on the day of dosing and twice daily thereafter.
- Necropsy of survivors performed: yes, all animals that died during the study and those sacrificed at termination were subjected to a gross necropsy and abnormalities were noted
- Other examinations performed: body weights were recorded initially, on days 8 and 15 or at death
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died prematurely
- Clinical signs:
- Anorexia observed in 3/5 males and 2/5 females
Diarrhea observed in 2/5 males and 3/5 females
Soft stools observed in 3/5 males and 4/5 females
Decreased activity observed in 3/5 females
Bloody stool observed in 1/5 females
Nasal discharge observed in 1/5 females - Body weight:
- No noteworthy findings
- Gross pathology:
- No noteworthy findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of bismuth neodecanoate (Cos Cat 83) is considered to be greater than 2.0 g/kg body weight. No classification for acute dermal toxicity is required.
- Executive summary:
Bismuth neodecanoate (Cos Cat 83) was evaluated for acute dermal toxicity in male and female New Zealand White rabbits. The test article was applied undiluted to each of ten rabbits at a level of 2.0 g/kg body weight. All animals survived the 15 day post-application observation period and no adverse clinical findings or body weight changes were observed. Based on these results, the acute dermal LD50 of the test article in considered to be greater than 2.0 g/kg body weight.
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