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Diss Factsheets
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EC number: 945-327-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- According to the secondary literature cited, the study was assigned reliability 2 (valid with restrictions; comparable to guidline study with acceptable restrictions).
Data source
Reference
- Reference Type:
- other: Collection of data from published literature and company data.
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
- Principles of method if other than guideline:
- Four animals per group used, two each treated on the intact and abraded skin: The substance was mixed with distilled water to form an aqueous
paste. Application to the intact and abraded skin under occlusive bandage. Observation period 14 d. - GLP compliance:
- no
Test material
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- ZEO 49, ZEOSYL 113, ZEOSYL 200, and ZEOFREE 153. Silica, precipitated, cryst.-free; CAS-No.: 112926-00-8.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- Four animals per group were used, two each treated on the intact and abraded skin: The substance was mixed with distilled water to form an aqueous paste. Application to the intact and abraded skin under occlusive bandage.
- Duration of exposure:
- Not specified.
- Doses:
- 2000, 3000, 4000 and 5000 mg/kg
- No. of animals per sex per dose:
- Four animals per group were used, two each treated on the intact and abraded skin. Sex not specified.
- Control animals:
- not specified
- Details on study design:
- Four animals per group were used, two each treated on the intact and abraded skin: The substance was mixed with distilled water to form an aqueous
paste. Application to the intact and abraded skin under occlusive bandage.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths.
- Clinical signs:
- other: Local effect: very slight erythema (score 1 of 4), reversible after 2 days (ZEO 49), after 4 d (ZEOSYL) or 5 d (ZEOFREE) in one or a few animals.
- Other findings:
- No systemic signs of toxicity or organ toxicity.
Applicant's summary and conclusion
- Conclusions:
- LD50 >5000 mg/kg.
- Executive summary:
An acute dermal toxicity study with precipitated synthetic amorphous silicon dioxide was carried out using rabbit as test organism. Four animals per group were used, two each treated on the intact and abraded skin. The substance was mixed with distilled water to form an aqueous paste and tested in four various doses (2000, 3000, 4000 and 5000 mg/kg). Application was done to the intact and abraded skin under occlusive bandage. The observation period covered 14 days.
Local effects such as very slight erythema (score 1 of 4) were observed which were reversible after 2 days
(ZEO 49), after 4 d (ZEOSYL) or 5 d (ZEOFREE) in one or a few animals. No systemic signs of toxicity or organ toxicity were documented.
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