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Diss Factsheets
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EC number: 604-012-2 | CAS number: 137296-15-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Radiolabelling:
- no
- Key result
- Type:
- Koc
- Value:
- ca. 1 L/kg
- Remarks on result:
- other: The Koc may vary by pH. The estimated value is applicable to the neutral pH range.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The adsorption/desorption coefficient of lactic acid was estimated to be approximately 1 L/kg using the QSAR model KOCWIN v2.00.
- Executive summary:
The adsorption/desorption coefficient of lactic acid was estimated to be approximately 1 L/kg using the QSAR model KOCWIN v2.00.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Endpoint:
- adsorption / desorption, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13 of.
- GLP compliance:
- no
- Type of method:
- other: literature review
- Media:
- soil
- Specific details on test material used for the study:
- - NH3 (un-ionized ammonia) and NH4+ (ionized ammonia or ammonium)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The environmental fate of ammonia (NH3) and Ammonium (NH4+) is discussed in the present report, hence fulfilling the scope of the OECD guideline 106, i.e. “predict partitioning under a variety of environmental conditions”. Ammonium is most likely to be found in soil, where it is adsorbed to the negatively charged soil particles. The adsorption mechanisms can be exchangeable (chemical binding), non-exchangeable (by fixation), reaction with organic matter and physical attractive forces. The report states that ammonia "is unlikely to leach to groundwater except under unusual circumstances, such as when the cation exchange capacity of the soil is exceeded.”because ammonia is poorly mobile in soil.
- Executive summary:
Ammonia/ammonium is strongly adsorbed on soil, sediment particles and colloids in water. This adsorption results in high concentrations of sorbed ammonia/ammonium in oxidised sediments. Under anoxic conditions, the adsorptive capacity of sediments is less, resulting in the release of ammonia to either the water column or an oxidized sediment layer above. In clay, ammonium tends to be absorbed on the negative adsorption sites of clay colloids. Ammonia/ammonium may substitute for potassium in the lattice structure of a clay mineral. Ammonia/ ammonium is bound in soil by the attraction of the positive charge on the ammonium ion to the negatively charged soil micelles. In soil, ammonium is adsorbed primarily by four mechanisms: chemical (exchangeable), fixation (non-exchangeable), reaction with organic matter and physical attractive forces.
Referenceopen allclose all
Description of key information
No experimental data on ammonium-S-lactate are available. In aqueous environments ammonium-S-lactate fully dissociates into NH4+ ions and lactate ions. Therefore, the adsorption/desorption behaviour of ammonium-S-lactate in the environment can be understood in terms of the adsorption/desorption behaviour of NH3/NH4+ and lactic acid. To evaluate the adsorption/desorption of ammonium-S-lactate read-across from lactic acid is performed.
An experimental study is scientifically not necessary since the log Pow for ammonium-S-lactate is expected to be low based on low log Pow values of both ionic components (below 0, respectively).
The adsorption/desorption coefficient of lactic acid was estimated to be approximately 1 L/kg using the QSAR model KOCWIN v2.00. Therefore, lactic acid is equally distributed between water and organic matter. Ammonia/ammonium is poorly mobile in soil. However, ammonium is a central element of the global natural nitrogen cycle and therefore of no concern in the context of the uses of ammonium-(S)-lactate.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1
Additional information
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.