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EC number: 279-013-0 | CAS number: 78948-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- method of the U.S. Federal Register, §191.12, 17 September 1964
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- Study was performed under the control of a quality assurance unit similar to GLP
Test material
- Reference substance name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- EC Number:
- 279-013-0
- EC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Cas Number:
- 78948-87-5
- Molecular formula:
- C16H8MgO10.2H
- IUPAC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Details on test material:
- Test material: Magnesium-monoperoxyphthalate-hexahydrate, H48 Bleach
- Source and lot/batch No.of test material: 0525
- Further relevant properties: White powder with a faint pungent odour
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Ranch Rabbits, Crawley Downi, Sussex
- Age at study initiation: 6 month
- Weight at study initiation: 4.08 - 5.60 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16+/-2
- Humidity (%): 50-70
- Air changes (per hr): 14
- Photoperiod (hrs dark / hrs light): 10/14
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg - Observation period (in vivo):
- 24, 48 and 72 h, 8 d
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:
criteria of Draize as required by the U.S. Federal Register, §191.12, 17 September 1964
TOOL USED TO ASSESS SCORE: not reported
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.6
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.4
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Remarks:
- redness
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Reevaluation of data presented in the report was performed in year 1994.
A single instillation of 100 mg H 48 bleach caused marked irritation of the cornea and conjunctiva of all rabbits, and of the iris of three animals, 24 hours later. At that time corneal lesions ranged from easily discernible translucent areas to nacreous areas obscuring the iris and affected areas ranging from less than a quarter up to the entire corneal surface . Conjunctival reaction consisted of diffuse crimson and, in one instance, beefy-redness, chemosis, ranging from obvious swelling with partial evers ion of the lids to complete closure, and was usually accompanied by some degree of ocular discharge.
These reactions occasionally intensified up to 72 hours after administration and all, except the iridial reaction of three rabbits, persisted at Day 8. The iridial reaction of the latter had resolved between 72 hours and seven days after administration. On Day 8 all animals presented pannus, which in one instance obscured the iris.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- H48 bleach showed severe irritation in the rabbit eye, when applied at doses of 100 mg. According to CLP GHS, H 48 bleach requires classification.
- Executive summary:
The eye irritation study was conducted in year 1981and new assessed in year 1994.
All animals of each treatment group displayed slight or moderate initial pain responses on instillation of test material. Under the conditions of this assessment each of the three treatments elicited marked ocular irritation.
Therefore, the test item will be classified as eye irritant.
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