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EC number: 245-912-1 | CAS number: 23850-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 1988 to 04 October 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- EC Number:
- 245-912-1
- EC Name:
- Butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- Cas Number:
- 23850-94-4
- Molecular formula:
- C28H54O6Sn
- IUPAC Name:
- butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- Test material form:
- liquid
- Details on test material:
- - Appearance: clear liquid with very slight yellow tint
- Storage: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (Sprague-Dawley derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: yes
- Age at study initiation: approximately 9 - 12 weeks old
- Weight at study initiation: Males: 289 - 351 g; Females: 214 - 260 g
- Fasting period before study: Animals were fasted overnight (for approximately 18 hours) prior to dosing
- Housing: Group-housed (six/cage) during equilibration and individually housed during study in suspended, stainless steel cages with wire mesh bottoms
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 21 or 22 days
ENVIRONMENTAL CONDITIONS
- Temperature: 67 - 76°F
- Humidity: 30 - 70%
- Photoperiod: 12 hours light, 12 hours dark (controlled by an automatic timer)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 4.6 mL/kg
- Doses:
- Range-finding study: 100, 500, 1000, 2500 and 5000 mg/kg
LD50 determination study: 2500, 3000, 3500 and 5000 mg/kg (3000 mk/kg: females only and 5000 mg/kg: males only) - No. of animals per sex per dose:
- Range-finding study: 1 animal per sex per dose
LD50 determination study: 5 animals per sex per dose (3000 mk/kg: females only and 5000 mg/kg: males only) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Viability Check: twice daily
Observations of Pharmacologic and Toxicological Signs: approximately 1, 2 and 4 hours after dosing and daily thereafter for fourteen days.
Body Weights: pre-fast (weights used for calculation of doses), day 7 and 14 and terminal: any animals which did not survive for 14 days were weighed at the time of death or at the time they were found dead.
- Necropsy of survivors performed: yes, gross post-mortem examinations were performed on all animals which died or were found dead during the study. At termination of the observation period (Day 14), all surviving animals were killed by carbon dioxide inhalation and examined grossly. All abnormalities
were recorded but no tissues were saved.
- Animals used for range-finding screens were observed for viability twice daily for seven days and deaths were recorded. No post-mortem examinations were made on animals used for range-finding screens.
Results and discussion
- Preliminary study:
- In the range-finding study, there were no deaths at 100, 500, 1000 or 2500 mg/kg but 2/2 animals died at 5000 mg/kg.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 871 - <= 3 529
- Mortality:
- - A sex-related difference was apparent, with females more affected than males. In males no mortality was seen at doses of up to 5000 mg/kg, while the LD50 in females was 3200 mg/kg.
- Mortality is summarised in Table 1. - Clinical signs:
- other: - Signs seen on the day of dosing in most or all groups included ataxia, nasal, oral and ocular discharge, hypopnea, hypoactivity, wet rales, faecal and urinary staining, irregular breathing and prostration. - On the day after dosing, unthrifty coat, hypo
- Gross pathology:
- - Gross post-mortem observations were generally unremarkable.
- Post-mortem examinations of animals which were found dead revealed changes which generally appeared to represent autolytic changes or normal variability.
- Changes in animals killed after 14 days were similar to those seen in control animals in this laboratory killed by carbon dioxide inhalation or were considered to represent normal physiological variation.
Any other information on results incl. tables
Table 1: Summary of Mortality During the Study
Dose Level (mg/kg) |
Mortality |
Time of Death |
|
Male |
Female |
||
2500 |
0/5 |
1/5 |
Day 1 |
3000 |
- |
0/5 |
- |
3500 |
0/5 |
4/5 |
22 hrs - Day 2 |
5000 |
0/5 |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU Criteria
- Conclusions:
- Under the conditions of this study the male LD50 was greater than 5000 mg/kg and the female LD50 was 3200 mg/kg.
- Executive summary:
The acute oral toxicity of the test material was investigated in a study similar to OECD 401.
During the study, male and female CD (Sprague-Dawley derived) rats were dosed with a single oral dose of the test material and observed for 14 days. The doses were chosen based on the results of a range finding study. For the definitive test males were dosed at 2500, 3500 and 5000 mg/kg and females were dosed at 2500, 3000 and 3500 mg/kg.
A sex-related difference was apparent, with females more affected than males. In males no mortality was seen at doses of up to 5000 mg/kg, while the LD50 in females was 3200 mg/kg.
Signs seen on the day of dosing in most or all groups included ataxia, nasal, oral and ocular discharge, hypopnea, hypoactivity, wet rales, faecal and urinary staining, irregular breathing and prostration. On the day after dosing, unthrifty coat, hypothermia, abdominal griping, soft stool and/or decreased food consumption were evident in some animals in all groups. Abnormalities continued in some animals for several days after dosing, but all animals were free of significant abnormalities at study termination (one male in the 5000 mg/kg group continued to exhibit an unthrifty coat).
The majority of surviving animals in the 2500 and 3000 mg/kg dose groups gained weight both 7 and 14 days after dosing. Several surviving animals in the 3500 and 5000 mg/kg dose groups exhibited weight losses at Day 7 but gained weight between Days 7 and 14. Gross post-mortem observations were generally unremarkable.
Under the conditions of this study the male LD50 was greater than 5000 mg/kg and the female LD50 was 3200 mg/kg.
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