Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Details on study design: HPLC method:
- Apparatus
Shimadzu UFLC:
SIL-20ACHT UFLC Autosampler
CTO-20AC Column Oven
LC-20AD Pump A
DGU-20A 3R Degassing Unit
CBM-20A System Controller
SPD-20A UV/VIS Detector
HPLC Conditions (Method 1)
Detector:
254 nm (Reference Items)
270 nm (Test Item)
Column: LiChrospher 100 CN (5μm) 250-4
Temperature: 25 °C
Mobil Phase: Methanol : Water = 55 : 45 (v/v)
Flow Rate: 1 mL/min
Injection volume: 5 μL
HPLC Conditions (Method 2)
Detector:
254 nm (Reference Items)
270 nm (Test Item)
Column: LiChrospher 100 CN (5μm) 250-4
Temperature: 25 °C
Mobil Phase: Methanol : 0.1 M citrate-buffer, pH 3.0 = 55 : 45 (v/v)
Flow Rate: 1 mL/min
Injection volume: 5 μL
HPLC Conditions (Method 3)
Detector:
254 nm (Reference Items)
270 nm (Test Item)
Column: LiChrospher 100 CN (5μm) 250-4
Temperature: 25 °C
Mobil Phase: Methanol : 0.1 M citrate-buffer, pH 6.1 = 55 : 45 (v/v)
Flow Rate: 1 mL/min
Injection volume: 5 μL
DETERMINATION OF DEAD TIME
Three series of sodium nitrate solution were injected.
REFERENCE SUBSTANCES
Reference substance CAS No. log Koc
Sodium nitrate 7631-99-4 -
Acetanilide 103-84-4 1.25
Methyl Benzoate 93-58-3 1.80
Linuron 330-55-2 2.59
Naphthalene 91-20-3 2.75
Pyrazophos 13457-18-6 3.65
Phenanthrene 85-01-8 4.09
DDT 50-29-3 5.63
DETERMINATION OF RETENTION TIMES
Chromatograms were evaluated using EZChrom Elite chromatogram processor software.
REPETITIONS
Three series of the above-mentioned reference solutions and the test item solution were measured. The retention times were determined.
EVALUATION
The capacity factors, k were calculated from the retention times (tR) of the selected reference items and the dead time (t0). Then the log k data of the reference items were plotted against their log Koc values. - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- < 1.5 dimensionless
- Temp.:
- 25 °C
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- < 1.5 dimensionless
- Temp.:
- 25 °C
- Key result
- Sample No.:
- #3
- Type:
- log Koc
- Value:
- < 1.5 dimensionless
- Temp.:
- 25 °C
- Details on results (HPLC method):
- Retention times measured for 7-ACA (1.28 minutes (Method 1), 2.63 minutes (Method 2) and 2.58 minutes (Method 3)) are lower than the retention time of the first eluting standard Acetanilide (3.33 minutes (Method 1), 3.31 minutes (Method 2) and 3.34 (Method 3)). This result shows that log Koc of 7-ACA is lower than the calibrated range. As the Acetanilide is the reference item with lowest Koc value, no further test was performed.
Using the HPLC method the log Koc of 7-ACA was determined to be < 1.5.
Quality criteria were met, as values of log Koc derived from individual measurements fell within a range of 0.25 log units.
The correlation coefficient R square for the relationship between log k and log Koc of the reference item was 0.990 (Method 1), 0.966 (Method 2) and 0.967 (Method 3).
The difference of the estimated log Koc to the known value of reference item fell within a range of ± 0.5 log units. - Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc of 7-ACA was determined to <1.5.
- Executive summary:
Using the HPLC method, the log Koc of 7-ACA was determined to <1.5.
Reference
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.5
Additional information
The Koc is not 1.5 but is <1.5, which can not be entered in the field above.
[LogKoc: 0.176]
[LogKoc: 0.176]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.