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EC number: 217-123-2 | CAS number: 1746-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2018-05-14 to 2018-06-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
- Details on sampling:
- At the start of the test five samples were taken from the test solutions and two samples were taken from the control buffers with two parallel of each. At the end of the test the treated samples were diluted with ultrapure water before the analysis. The control samples were measured without dilution.
- Buffers:
- - pH: 4
- Composition of buffer: 6.45 g citric acid monohydrate, 13.8 g di-sodium hydrogen phosphate dodecahydrate in 500 mL ultrapure water
- pH: 7
- Composition of buffer: 74 mL 0.2 M sodium hydroxide, 125 mL 0.2 M potassium dihydrogen phosphate in 500 mL ultrapure water
- pH: 9
- Composition of buffer: 53.5 mL 0.2 M sodium hydroxide, 125 mL 0.2 M boric acid - potassium chloride solution in 500 mL ultrapure water - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: screw-cap glass tubes with PTFE septa
- Sterilisation: yes
- Lighting: no
- Measures taken to avoid photolytic effects: The test was performed under darkness to avoir photolytic effects.
- Measures to exclude oxygen: Nitrogen was bubbled into the water for five minutes before the preparation of the solutions in order to exclude oxygen.
- If no traps were used, is the test system closed/open: closed with PTFE septa
TEST MEDIUM
- Volume used/treatment; 500 mL
- Kind and purity of water: ultrapure
OTHER TEST CONDITIONS
- Adjustment of pH: no - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 032.5 - <= 1 047.7 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 050.9 - <= 1 073.3 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 022 - <= 1 041.4 mg/L
- Number of replicates:
- 5
- Positive controls:
- no
- Negative controls:
- yes
- Preliminary study:
- Hydrolysis at pH 4, 7 and 9 was not observed - 0 to 2 % of the test item hydrolysed after 5 days. Therefore, the test item is considered to be hydrolytically stable and no main test was performed.
- Transformation products:
- not measured
- % Recovery:
- ca. 102
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- ca. 101
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- ca. 102
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item was determined to be hydrolytically stable at pH 4, 7 and 9 in the preliminary test.
- Executive summary:
The hydrolysis of the test item was assessed in accordance with the OECD guideline 111 and the EU method C.7 in a preliminary test. The hydrolysis of the test item in different aqueous buffer solutions (pH = 4, 7 and 9) at 50 °C was investigated using HPLC-UV. The content of test item in the different pH buffer samples was determined at the beginning and the end of the test period. Five samples of the test item solutions were analysed at the start of the study. Two samples were taken from the control vessels at the start and at the end of the storage and these were measured without dilution. Less than 10 % of hydrolysis was observed after 5 days at each pH value. Based on the results obtained, test substance can be considered to be hydrolytically stable at pH 4, pH 7 and pH 9 under the conditions investigated.
Reference
Description of key information
The test item was determined to be hydrolytically stable at pH 4, 7 and 9 in the preliminary test.
Key value for chemical safety assessment
Additional information
The hydrolysis of the test item was assessed in accordance with the OECD guideline 111 and the EU method C.7 in a preliminary test. The hydrolysis of the test item in different aqueous buffer solutions (pH = 4, 7 and 9) at 50 °C was investigated using HPLC-UV. The content of test item in the different pH buffer samples was determined at the beginning and the end of the test period. Five samples of the test item solutions were analysed at the start of the study. Two samples were taken from the control vessels at the start and at the end of the storage and these were measured without dilution. Less than 10 % of hydrolysis was observed after 5 days at each pH value. Based on the results obtained, test substance can be considered to be hydrolytically stable at pH 4, pH 7 and pH 9 under the conditions investigated.
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