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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 09, 2017 to March 06, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181: Solubility in organic solvents
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- The study was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however no claim of GLP compliance was intended nor is made for this study
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 35.5 g/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Conclusions:
- Under study conditions, the n-octanol solubility of the test substance, was determined to be in range of 35.5 g/L at 20.0 ± 0.5°C.
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, at 20˚C, according to CIPAC MT 181 (solubility in organic solvents). The preliminary estimate of the octanol solubility at 20.0 ± 0.5 °C was >4.9 g/L. The mean of the definitive test tested at 50 g/L adn 60 g/L using adapted flask method was determined to be 35.5 g/L at 20.0 ± 0.5°C. Under study conditions, the n-octanol solubility of the test substance, was determined to be 35.5 g/L at 20.0 ± 0.5°C (Envigo, 2018).
Reference
Results:
Preliminary Test (MT 181)
The recorded observations for the contents of the cylinder after each addition ofn-octanol are shown in the following table:
Total Volume of n-Octanol Added (mL) |
Saturation Concentration (g/L) |
Observations |
0.5 |
204 |
Opaque, white liquid with excess test item present |
1 |
102 |
Transparent, colorless liquid with excess test item present |
2 |
51.1 |
Transparent, colorless liquid with excess test item present |
3 |
34.0 |
Transparent, colorless liquid with excess test item present |
4 |
25.5 |
Transparent, colorless liquid with excess test item present |
5 |
20.4 |
Transparent, colorless liquid with excess test item present |
10 |
10.2 |
Transparent, colorless liquid with excess test item present |
The solubility was estimated to beless than 10g/L anddefinitivetesting was continued using theadapted flask method.
Preliminary Test(Adapted Flask Method): The preliminary estimate of the octanol solubility at 20.0 ± 0.5 °C was >4.9 g/L
Definitive Test(Adapted Flask Method)
The mean peak areas relating to the 50 g/L loading ratesolutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 1.53 x 103mg/L |
4.4995 x 107 |
Standard 1.23 x 103mg/L |
3.5024 x 107 |
Standard 1.02 x 103mg/L |
2.8600 x 107 |
Standard 767 mg/L |
1.7926 x 107 |
Standard 516 mg/L |
1.0730 x 107 |
Standard 256 mg/L |
3.6005 x 106 |
Standard 102 mg/L |
9.2100 x 105 |
Matrix blank |
None detected |
Sample 1A |
1.6185 x 107 |
Sample 1B |
1.5962 x 107 |
Sample 2A |
1.9103 x 107 |
Sample 2 B |
1.8515 x 107 |
The mean peak areas relating to the 60 g/L loading ratesolutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 1.54 x 103mg/L |
4.6078 x 107 |
Standard 1.23 x 103mg/L |
3.2912 x 107 |
Standard 1.03 x 103mg/L |
2.6134 x 107 |
Standard 769 mg/L |
1.7527 x 107 |
Standard 506 mg/L |
9.9511 x 106 |
Standard 256 mg/L |
3.7553 x 106 |
Standard 103 mg/L |
9.0987 x 105 |
Matrix blank |
None detected |
Sample 4A |
1.6873 x 107 |
Sample 4B |
1.7022 x 107 |
Sample 5A |
1.4424 x 107 |
Sample 5 B |
1.4969 x 107 |
Sample 6A |
1.4872 x 107 |
Sample 7B |
1.4873 x 107 |
Description of key information
The n-octanol solubility of the test substance was determined according to CIPAC MT 181: solubility in organic solvents (Envigo, 2018).
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 35.5 g/L
Additional information
Value used for CSA: 35.5 g/L at 20°C
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