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EC number: 244-971-0 | CAS number: 22413-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue justification attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Source, CAS 36078-10-1, Dako, 2012, activated sludge microorganims
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Source, CAS 36078-10-1, Dako, 2012, activated sludge microorganisms
- Conclusions:
- The key values for the toxicity to activated sluge microorganisms are a NOEC (3 h) of ≥ 1000 mg/L (nominal), based on experimental data with two structurally and chemically closely related source substances (OECD 209, activated sludge).
Reference
Description of key information
NOEC (3 h)>= 1000 mg/L (OECD 209, read-across)
Key value for chemical safety assessment
Additional information
Since no studies are available investigating the toxicity to microorganisms of Docosyl stearate (CAS 21443-03-2) a read-across to the structurally related source substances dodecyl oleate (CAS 36078-10-1) and 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) were conducted, in accordance to Regulation (EC) No 1907/2006 Annex XI. The source substances are considered to be representative to evaluate the short-term toxicity of Docosyl stearate (CAS 21443-03-2) to aquatic microorganisms. The target substance is an ester of stearic acid (C18) and docosanol (C22). The source substance Dodecyl oleate (CAS 36078-10-1) is an ester of similar fatty acid (C18:1) and a shorter chain alcohol (C12). 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) is described by isostearic acid (C18) and a branched alcohol (C20) with comparable chain length to the target substance). The source substances are therefore considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic microorganisms.
This read-across is justified in detail within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the read-across substance dodecyl oleate (CAS 36078-10-1) to activated sludge microorganisms was performed according to OECD 209 using activated sludge from a predominantly domestic sewage treatment plant. A limit test with a nominal concentration of 1000 mg/L was performed for 3 h. The respiration rate of activated sludge microorganisms was not inhibited resulting in a NOEC (3 h) of ≥ 1000 mg/L. Thus, it can be concluded that no toxicological effects of dodecyl oleate on microorganisms are expected.
Furthermore a biodegradation test conducted according to OECD guideline 301B is available as supporting study investigating the effects of the read-across substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) (Desmares-Koopmans, 1998). The test includes a toxicity control, which contains 14.2 mg/L of the test substance and 39.85 mg/L of the reference material. The toxicity control attained 78.1% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms and a NOEC (14 d) of ≥ 14.2 mg/L was derived.
Based on the available result from two structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that docosyl stearate (CAS 22413-03-2) will not inhibit the degradation process in sewage treatment plants.
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