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EC number: 216-703-2 | CAS number: 1644-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- A historical in vivo ocular irritation study was conducted on the test substance in the year 2000, prior to in vitro test methods being required.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- A historical in vivo ocular irritation study was conducted on the test substance in the year 2000, prior to in vitro test methods being required.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane
- EC Number:
- 216-703-2
- EC Name:
- 1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane
- Cas Number:
- 1644-11-7
- Molecular formula:
- C8F16O2
- IUPAC Name:
- 1,1,1,2,2,3,3-heptafluoro-3-({1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propan-2-yl}oxy)propane
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch: 19B 2059
- Expiration date of the lot/batch: 14 January, 2001
- Purity test date: 14 January, 2000
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Darkness at approximately 20C in a fume cupboard under inter (N2) conditions.
- Stability under test conditions: No data
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH
- Age at study initiation: No data
- Weight at study initiation: 2.7-3.7 kg
- Housing: Individually
- Diet (e.g. ad libitum): ssniff K-H (V2333), ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: 1 week under study conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23 C
- Humidity (%): 30-70 %
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 March, 2000 To: 24 March, 2000
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
VEHICLE: None - Duration of treatment / exposure:
- Eyes were washed with isotonic saline 24 hours after instillation of the test article.
- Observation period (in vivo):
- The eyes were examined 1, 24, 48, and 72 hours after administration of the test article.
- Number of animals or in vitro replicates:
- 3 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 24 hours after instillation with isotonic saline
- Time after start of exposure: 24 hours
SCORING SYSTEM: DRAIZE: Cornea opacity: 0-4, Iritis: 0-2, Conjunctivae redness: 0-3, chemosis: 0-4, discharge: 0-3
TOOL USED TO ASSESS SCORE: hand-slit lamp and fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- One hour after administration the conjunctivae of one animal had definitively injected blood vessels. 24 hours after administration, all signs of irritation had resolved.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- On hour after administration of the test article, the conjunctivae of one animal had definitively injected blood vessels. 24 hours after administration, all signs of irritation had resolved. No other signs of irritation were observed in any other animals at any other time points.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, the test article is not an ocular irritant.
- Executive summary:
The primary eye irritation/corrosion potential of the test article was evaluated in New Zealand White Rabbits. This study was performed in accordance with OECD GLP (1999). The study design was based on OECD 405 (1987) and Directive 92/69/EEC guideline B.5 (1992). Approximately 24 hours prior to the study the eyes of all animals were examined using a fluorescein solution. Animals without ocular abnormalities were selected for this study. The test material (0.1 mL) was administered as received to the conjunctival sac of the left eye of three rabbits. The contralateral eye served as the control. The treated eyes were washed with 37 C saline at 24 hours post-dose. The eyes were examined for irritation of the cornea, iris and conjunctiva at 1, 24, 48 and 72 hours post-dose using the Draize technique. Sodium fluorescein dye procedures were used at 24 and 72 hours after dosing to improve the evaluation of the cornea. One hour after dosing, the conjunctivae of one animal showed definitely injected blood vessels (score: 1). At 24 hours after dosing, all animals were normal. Based on the results of this study, the test article is not an ocular irritant.
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