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EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2,6-Diisopropylnaphthalene
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: bulk
- >= 90 - <= 99.9 % (w/w)
- Reference substance:
- 2,6-Diisopropylnaphthalene
- Reference substance:
- 2,6-Diisopropylnaphthalene
- This impurity is considered relevant for the classification and labelling of the substance
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence Assessment
No biodegradation study concerning only 2,6-diisopropylnaphthalene (2,6-DIPN) is available. Bis(isopropyl)naphthalene (DIPN) is an isomeric mixture, which consist of seven isomers (1,3-, 1,4-, 1,5-, 1,6-, 2,6- and 2,7-DIPN). In a sealed vessel CO2 headspace test using 14C ring labelled diisopropylnaphthalene isomer mixture, no ultimate biodegradation could be demonstrated. Analysing DIPN content in test medium, mean primary biodegradation (ca. 20 - 25%) was observed, while the degree of primary degradation was ~100% after 28 days for 2,6-DIPN. On the other hand, ultimate degradation could not be concluded for the target substance, 2,6-DIPN.
Therefore 2,6-diisopropylnaphthalene (CAS: 24157-81-1; 2,6-DIPN) needs to be assessed as potentially persistent (P) and/or very persistent (vP).
Bioaccumulation Assessment
No bioaccumulation study concerning only 2,6-diisopropylnaphthalene (2,6-DIPN) was available. But a GLP study according to OECD 305 examining the bioaccumulative potential of Bis(isopropyl)naphthalene (DIPN), an isomeric mixture which consist of seven isomers (1,3-, 1,4-, 1,5-, 1,6-, 2,6- and 2,7-DIPN) is available and used in a read-across approach. In this study the BCF values of the seven isomers was determined individually for each isomer. The determined BCF values differed strongly between the isomers.
According to the recent OECD 305 (2012) as well as the ECHA Guidance Document R.11 (v2.0, 2014), the BCF values should be expressed based on a 5% lipid content. In the original study report the BCF data were not lipid-normalised. Therefore, in an expert statement by ECT Oekotoxikologie GmbH (ETC, 2017) a lipid-normalisation was performed using the data (BCF and lipid content) available in the original study report.
For 2,6-DIPN the lipid normalized BCF values were determined as 810 (low dose group; 0.47 µg/L) and 2200 (high dose group; 4.85 µg/L), respectively. Hence, 2,6-DIPN fulfils the criterion of being bioaccumualtive (BCF > 2000) but not very bioaccumulative (BCF < 5000).
Although the environmental relevance of the results from the high exposure concentration is questionable (see expert statement ETCECT, 2017) the highest measured BCF value of 2200 was used as an worst case assumption for the bioaccumulation assessment. Therefore, 2,6-diisopropylnaphthalene (CAS24157-81-1)DIPN was assessed as bioaccumulative (B) but not very bioaccumulative (vB) under environmental conditions.
Toxicity Assessment
No chronic ecotoxicological study concerning only 2,6-diisopropylnaphthalene (2,6-DIPN) is available. But a long-term toxicity study on Daphnia magna following OECD guideline 211 examining Bis(isopropyl)naphthalene (DIPN), an isomeric mixture which consist of seven isomers (1,3-, 1,4-, 1,5-, 1,6-, 2,6- and 2,7-DIPN) is available and used in a read-across approach. In this study a NOEC (21 d) of 0.0118 mg/L (measured, TWA) based on the reproduction rate was determined. This result should be used as a worst-case since 1,3- and 1,4-DIPN were identified by ECHA as the most critical isomers with regards to aquatic toxicity. Even individual studies with those critical isomers resulted in effect concentrations above the trigger meeting the T-criterion. Based on further available data, the substance2,6-DIPN is not classified as carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation (EC) No 1272/2008. Hence, the T T-criterion is not fulfilled.
In conclusion, the substance the substance is not a PBT or a vPvB substance.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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