Registration Dossier
Registration Dossier
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EC number: 910-427-2 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- early life stage, adult fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target substance Zinc peroxide and the source substances Zinc oxide, Zinc Chloride, Zinc sulfate, Zinc nitrate are ionic and consist of the Zinc2+ cation and the respective anion.
The read-across is based on the assumption that the zinc cation (as measure for dissolved zinc species) is the determining factor for (eco)toxicity.
For further details, see Justification for read-across attached to IUCLID chapter 13
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See Justification for read-across attached to IUCLID chapter 13
3. ANALOGUE APPROACH JUSTIFICATION
See Justification for read-across attached to IUCLID chapter 13
4. DATA MATRIX
See Justification for read-across attached to IUCLID chapter 13 - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Remarks:
- freshwater
- Effect conc.:
- >= 44 - <= 530 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: Zn2+
- Basis for effect:
- other: growth, mortality
- Duration:
- 27 d
- Dose descriptor:
- NOEC
- Remarks:
- marine
- Effect conc.:
- 25 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: Zn2+
- Basis for effect:
- other: growth, mortality
- Conclusions:
- The NOEC of Zn2+ in freshwater fish ranged from 44 to 530 µg/L; the NOEC of Zn2+ in marine fish was 25 µg/L.
Reference
Description of key information
freshwater:
Data on 7 species available. Species NOECs range between 0.044 and 0.530 mg Zn/l (dissolved concentrations)
Marine:
Data on 1 species available. NOEC = 0.025 mg Zn/l (dissolved concentrations)
Species NOECs have been put into the respective species sensitivity distributions.
For ZnO nano form, only one study is of good quality but only compares ZnO bulk and zinc ion at one dose for control and the concentrations are nominal. Additionally, it gives unbound NOECs. It concludes though that ZnO bulk and ionic form of zinc are more toxic at equal dose. No value is retained for long-term toxicity in fish.
Key value for chemical safety assessment
Additional information
Extensive high quality chronic data were available on 7 (freshwater) and 1 (marine) fish species. These data were all screened for relevancy to the environment under study.
The freshwater species are part of 4 families: Cyprinodontidae (Jordanella), Cyprinidae (Phoxinus, Pimephales), Salmonidae (Oncorrhynchus, Salvelinus, Salmo trutta) and Cottidae (Cottus). The sensitivity of these species is equally distributed over the species sensitivity distribution. The fish species NOECs are combined with the other freshwater chronic data in the SSD to give the HC5 from which the PNEC is derived.
The saltwater species comes from the family Clupeidae (Clupea harengus). This species is not among the most sensitive ones in the species sensitivity distribution. The fish species NOEC is combined with the other marine chronic data in the SSD to give the HC5 from which the PNEC saltwater is derived.
The available short-term ecotoxicity data on hydrogen peroxide demonstrate, that Zn2+ is the determining factor for ecotoxicity, thus, futher long-term toxicity data are not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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