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Diss Factsheets
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EC number: 202-495-0 | CAS number: 96-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on LLNA data supported by read-across from a GPMT with GMT, monothioglycerol is considered a moderate skin sensitizer.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- 2010
- Deviations:
- yes
- Remarks:
- TS not characterised
- Principles of method if other than guideline:
- LLNA with pre-guidleine methodology
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
- Specific details on test material used for the study:
- purchased from Fluka
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- Age: 8-12 wk
- Vehicle:
- dimethylformamide
- Concentration:
- 10.0%, 25.0%, 50.0%
- No. of animals per dose:
- 4
- Details on study design:
- Mice received daily topical application for 3 consecutive days with 25 µL of one of three concentrations of the test chemical on the dorsum of each ear. Control mice were treated with vehicle alone in an identical manner. 5 days after the first topical application, all mice were injected iv with 250 µL PBS containing 20 µCi of [³H]methyl thymidine
- Positive control substance(s):
- not specified
- Positive control results:
- not required
- Key result
- Parameter:
- EC3
- Value:
- 3.9
- Test group / Remarks:
- Interpolated from the SI values at 0%, 10%, and 25%
- Key result
- Parameter:
- SI
- Value:
- 6.7
- Test group / Remarks:
- 10.0%
- Parameter:
- SI
- Value:
- 10
- Test group / Remarks:
- 25.0%
- Parameter:
- SI
- Value:
- 10
- Test group / Remarks:
- 50.0%
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- TB showed an EC3 of ca. 4%. It is therefore considered a moderate skin sensitizer (Skin Sens 1B).
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see attached justification
- Reason / purpose for cross-reference:
- read-across source
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- - Intradermal induction : 1% w/v of the supplied test material in distilled water
- Topical lnduction : 10% v/v of the supplied test material in distilled water
- Topical Challenge : 10% and 5% v/v of the supplied test material in distilled water - No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- - Intradermal induction : 1% w/v of the supplied test material in distilled water
- Topical lnduction : 10% v/v of the supplied test material in distilled water
- Topical Challenge : 10% and 5% v/v of the supplied test material in distilled water - Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10 % v/v
- No. with + reactions:
- 9
- Total no. in group:
- 20
- Clinical observations:
- erythema and oedema formation up to score of 2
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 10 % v/v. No with. + reactions: 9.0. Total no. in groups: 20.0. Clinical observations: erythema and oedema formation up to score of 2.
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10 % v/v
- No. with + reactions:
- 10
- Total no. in group:
- 20
- Clinical observations:
- erythema and oedema formation up to score of 2, desquamation
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 10 % v/v. No with. + reactions: 10.0. Total no. in groups: 20.0. Clinical observations: erythema and oedema formation up to score of 2, desquamation.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 10% v/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 10% v/v. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 10% v/v
- No. with + reactions:
- 5
- Total no. in group:
- 10
- Clinical observations:
- no erythema or edema, only slight desquamation
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 10% v/v. No with. + reactions: 5.0. Total no. in groups: 10.0. Clinical observations: no erythema or edema, only slight desquamation.
- Reading:
- other: incidence of sensitisation
- Group:
- positive control
- Dose level:
- 25% MBT in acetone PEG 400 (70:30)
- No. with + reactions:
- 9
- Total no. in group:
- 10
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- Based on read across from GMT, TG is considered a moderate sensitizer to guinea pig skin.
Referenceopen allclose all
TG was also positive in 100% of participants in a human maximization test using 10% and 5% TG for induction and challenge, respectively.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
TG was also positive in 100% of participants in a human maximization test using 10% and 5% TG for induction and challenge, respectively.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
TG had an EC3 of > 2% in an LLNA. The surrogate substance GMT had 50% responding animals in a GPMT at 1% intradermal induction dose. Therefore, TG is classified as moderate skin sensitizer (Skin Sens 1B)
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