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Diss Factsheets
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EC number: 201-744-0 | CAS number: 87-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 7 Jun - 12 Jul 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The skin sensitization potential of the test substance at a 10% concentration w/w in alcohol:DEP (75:25) was assessed in a human repeat patch study. A total of 51 subjects participated in the study. Subjects were exposed to 10 induction patches containing 0.2 mL of the test substance at 10% w/w in alcohol:DEP (75:25) under occlusive conditions on a Monday, Wednesday and Friday schedule. Patches were removed 24 hours after each application and patch sites were graded at 48 hours after patch application prior to the next patch application. After a 2-weeks rest period, subjects were challenged with 0.2 mL test substance at 10% w/w in alcohol:DEP (75:25) (24 hour patch exposure). Challenge patch sites were graded at 24, 48 and 72 hours after patch application.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalide
- EC Number:
- 201-744-0
- EC Name:
- Phthalide
- Cas Number:
- 87-41-2
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1-one
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- confirmed, but no further information available
- Subjects:
- - Number of subjects exposed: 43 females, 8 males
- Age: 19-7 years - Controls:
- Untreated skin served as control.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: repeat insult patch test (HRIPT)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Coverlet adhessive dressing (Beiersdorf Inc.)
- Vehicle / solvent: alcohol:DEP (75:25)
- Concentrations: 10%
- Volume applied: 0.2 mL
- Testing/scoring schedule:
Induction:
Monday, Wednesday and Friday for a total of 10 applications
patch sites were graded at 48 hours after patch application prior to the next patch application
Challenge:
after a 2-weeks rest period for 24 h
- Removal of test substance: 24 h
EXAMINATIONS
- Grading/Scoring system:
0 - No visible reaction
1 - Mild erythema
2 - Well-defined erythema, possible presence of barely perceptible edema
3 - Erythema and edema
4 - Erythema and edema with vesiculation and ulceration
Results and discussion
- Results of examinations:
- No skin reaction was observed after application of the 10% test substance solution throughout the study.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the test substance at 10% w/w in alcohol:DEP (75:25) did not indicate any skin irritation or sensitization potential.
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