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Diss Factsheets
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EC number: 915-318-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24th January 2019 - 21st February 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of 1,2,3,4,4a,5,6,7-octahydro-2,5,5-trimethyl-2-naphthol and 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one and 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
- EC Number:
- 915-318-3
- Cas Number:
- 41199-19-3, 17283-81-7 and 31499-72-6
- IUPAC Name:
- Reaction mass of 1,2,3,4,4a,5,6,7-octahydro-2,5,5-trimethyl-2-naphthol and 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one and 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Details on sampling:
- The test sample and HCO-40 were dissolved in N,Ndimethylformamide to prepare stock solution. This tsock solution was diluted appropriately with dilution water to prepare the test solution.
Test solutions
- Vehicle:
- yes
- Remarks:
- feed
- Details on preparation of test solutions, spiked fish food or sediment:
- Feed: Feed for colored carp
Composition: Proteins content 230%
Lipid content 24.0%
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Age at study initiation: Yearling fish
- Length at study initiation: 6.2- 6.7 cm
- Weight at study: The minimum fish weight at the beginning of uptake phase was more than two thirds of the maximum one.
- Feeding during test
- Food type: Feed for colored carp
- Amount: 2% of total body weight
- Frequency: daily
ACCLIMATION
- Acclimation period: 90 days
- Acclimation conditions: 25+/-2°C
Study design
- Route of exposure:
- feed
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 28 d
Test conditions
- Hardness:
- 1 8.8 mgCaCO3/L
- Test temperature:
- 25.0-25.2°C
- pH:
- 7.6-7.5
- Dissolved oxygen:
- 7.0-7.6 mg/L
- TOC:
- 9.41-10.2 mgCL
- Details on test conditions:
- Aeration No aeration
Time of irradiation with light: 14 hours light 11 0 hours dark (artificial light of white fluo-t lamp)
Number of fish (at the beginning of uptake phase)
Levels 1 and 2: 32 fish/ level
Control 1: 6 fish/ level - Nominal and measured concentrations:
- 0.1 and 0.01 mg/L
- Reference substance (positive control):
- no
Results and discussion
Lipid contentopen allclose all
- Lipid content:
- 4.22 %
- Time point:
- start of exposure
- Lipid content:
- 4.89 %
- Time point:
- end of exposure
Bioaccumulation factoropen allclose all
- Key result
- Conc. / dose:
- 0.1 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Type:
- BCF
- Value:
- < 28 L/kg
- Basis:
- total lipid content
- Calculation basis:
- steady state
- Key result
- Conc. / dose:
- 0.01 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Type:
- BCF
- Basis:
- total lipid content
- Calculation basis:
- steady state
- Remarks on result:
- not determinable
Rate constants
- Key result
- Rate constant:
- growth rate constant (d-1)
- Value:
- 0.016
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The bioconcentration factor for a 0.1 mg/L concentration was 28 L/Kg at steady state and was not determinable at 0.01 mg/L concentration.
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