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EC number: 247-956-7 | CAS number: 26748-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977-09-02 to 1978-02-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-methyl-1-phenylethyl peroxyneodecanoate
- EC Number:
- 247-956-7
- EC Name:
- 1-methyl-1-phenylethyl peroxyneodecanoate
- Cas Number:
- 26748-47-0
- Molecular formula:
- C19H30O3
- IUPAC Name:
- 1-methyl-1-phenylethyl 2-ethyl-2,5-dimethylhexaneperoxoate
Constituent 1
- Specific details on test material used for the study:
- - Name: Cumyl peroxyneodecanoate (SN-1-4462-71)
- Purity: 90.2%
- Appearance: viscous yellowish liquid
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Portage, Michigan
- Weight at study initiation: 200 - 248 g
- Housing: Animals were housed by sex in groups of 5 rats per cage in hanging wire-mesh cages
- Water: ad libitum
- Diet: ad libitum; Purina Laboratory Chow (withheld during overnight period preceding oral administration)
- Temperature and humidity controlled quarters
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- once (to male and female): 2034, 3229, 5126, 8137, 12918 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
OBSERVATIONS
- Weighing: Initially, at 7 and 14 days
- Mortality/Viability: During first four hours after dosing, at 24 hours and daily thereafter - Statistics:
- Statistical Reference
LD50 values and associated 95% confidence interval, slope of dose mortalitiy curve
References:
- Weil, C.S. 1952. Tables for Convenient Calculation of Median Effective Dose and Instruction in Their Use. Biometrics, 8: 249 - 263
- Thompson, W.R. and Weil, C.S. 1952. On the Construction of Tables for Moving Average Interpolation. Biometrics, 8: 51 - 54
- Eby, R. 1957. Statistical Tables for Dose Evaluation, Report No. 5711. Miles - Ames Research Laboratoy, Elkhart, Indiana
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 068 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 132 - <= 5 284
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 458 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 5 590 - <= 7 462
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 126 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4 294 - <= 6 118
- Mortality:
- At 8137 and 12918 mg/kg all animals died. At 5126 mg/kg 4/5 female animals were found dead and at 3229 mg/kg 1/5 female animals died. No deaths occured at a dose of 2034 mg/kg.
For individual results see Table 1 in box 'Any other information on results incl. tables'. - Clinical signs:
- No data
- Body weight:
- A trend in decreasing body weight gain is observed in survived animals.
For individual results see Table 1 in box 'Any other information on results incl. tables'. - Gross pathology:
- No data
Any other information on results incl. tables
Table 1: Mortality and LD50 Values
Exposure Conc. mg/kg |
Number of Deaths |
Total Mortalities |
|||||||||||||||||
|
Postexposure |
||||||||||||||||||
Hrs. |
Days |
||||||||||||||||||
0 - 4 |
1 |
2 |
3 |
4 |
5 |
6 |
7 - 14 |
||||||||||||
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
Male |
Female |
Total |
|
2034 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0/5 |
0/5 |
0/10 |
3229 |
|
|
|
|
|
|
|
1 |
|
|
|
|
|
|
|
|
0/5 |
1/5 |
1/10 |
5126 |
|
|
|
2 |
|
2 |
|
|
|
|
|
|
|
|
|
|
0/5 |
4/5 |
4/10 |
8137 |
1 |
3 |
3 |
2 |
|
|
1 |
|
|
|
|
|
|
|
|
|
5/5 |
5/5 |
10/10 |
12918 |
5 |
5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5/5 |
5/5 |
10/10 |
The Acute Oral LD50 Values and 95% Confidence Limits
Male Rats: 6458 (5590 - 7462)
Female Rats: 4068 (3132 - 5284)
Combined Male and Female Rats: 5126 (4294 - 6118)
Slope
Male Rats: 1.66
Female Rats: 1.66
Combined Male and Female Rats: 1.66
Table 2: Body Weights obtained during 14 -day observation period
Dosage Level mg/kg |
Individual Rat No. |
Sex |
Control Weight (grams) |
7-Day Weight (grams) |
14-Day Weight (grams) |
2034 |
70485 |
Male |
211 |
295 |
334 |
70486 |
Male |
231 |
272 |
286 |
|
70487 |
Male |
244 |
312 |
343 |
|
70488 |
Male |
248 |
296 |
323 |
|
70498 |
Male |
243 |
291 |
324 |
|
70490 |
Female |
214 |
248 |
256 |
|
70491 |
Female |
210 |
243 |
258 |
|
70492 |
Female |
208 |
242 |
273 |
|
70493 |
Female |
202 |
247 |
254 |
|
70494 |
Female |
200 |
224 |
243 |
|
3229 |
70354 |
Male |
200 |
258 |
310 |
70355 |
Male |
221 |
245 |
292 |
|
70356 |
Male |
215 |
281 |
312 |
|
70357 |
Male |
201 |
264 |
324 |
|
70358 |
Male |
213 |
280 |
325 |
|
70349 |
Female |
212 |
234 |
226 |
|
70350 |
Female |
200 |
240 |
246 |
|
70351 |
Female |
214 |
238 |
260 |
|
70352 |
Female |
200 |
Died |
Died |
|
70353 |
Female |
216 |
252 |
241 |
|
5126 |
70364 |
Male |
200 |
211 |
222 |
70365 |
Male |
201 |
244 |
308 |
|
70366 |
Male |
205 |
269 |
318 |
|
70367 |
Male |
202 |
225 |
258 |
|
70368 |
Male |
207 |
248 |
288 |
|
70359 |
Female |
200 |
235 |
216 |
|
70360 |
Female |
200 |
Died |
Died |
|
70361 |
Female |
201 |
Died |
Died |
|
70362 |
Female |
220 |
Died |
Died |
|
70363 |
Female |
210 |
Died |
Died |
|
8137 |
70374 |
Male |
201 |
Died |
Died |
70375 |
Male |
203 |
Died |
Died |
|
70376 |
Male |
208 |
Died |
Died |
|
70377 |
Male |
205 |
Died |
Died |
|
70378 |
Male |
200 |
Died |
Died |
|
70369 |
Female |
210 |
Died |
Died |
|
70370 |
Female |
218 |
Died |
Died |
|
70371 |
Female |
220 |
Died |
Died |
|
70372 |
Female |
206 |
Died |
Died |
|
70373 |
Female |
204 |
Died |
Died |
|
12918 |
70384 |
Male |
215 |
Died |
Died |
70385 |
Male |
200 |
Died |
Died |
|
70386 |
Male |
210 |
Died |
Died |
|
70387 |
Male |
200 |
Died |
Died |
|
70388 |
Male |
200 |
Died |
Died |
|
70379 |
Female |
204 |
Died |
Died |
|
70380 |
Female |
200 |
Died |
Died |
|
70381 |
Female |
210 |
Died |
Died |
|
70382 |
Female |
210 |
Died |
Died |
|
70383 |
Female |
202 |
Died |
Died |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The presented studies finds that 1-Methyl-1-phenylethyl peroxyneodecanoate is not of acute oral toxicity and that GHS criteria are not met.
- Executive summary:
In a primary acute oral toxicity study (similar to OECD 401), Charles River CD rats (5/sex/dose) were orally exposed to 2034, 3229, 5126, 8137 and 12918 mg/kg bw Cumyl peroxyneodecanoate (1-Methyl-1-phenylethyl peroxyneodecanoate, 90.2% purity), suspended in corn oil. Animals then were observed for 14 days. Due to mortality distribution, the oral LD50 in rats in considered to be 6458 mg/kg bw for males, 4068 mg/kg bw for females and 5126 mg/kg bw for both sexes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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