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Diss Factsheets
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EC number: 931-227-1 | CAS number: 28497-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OECD Toolbox Version 3.4
2. SMILES
O=C(C(=C)C)OCC(COC(=O)C(=C)C)O
3. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
sse attachment - Principles of method if other than guideline:
- - Software tool(s) used including version: OECD Tollbox 4.1
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' - GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES Structure: O=C(C(=C)C)OCC(COC(=O)C(=C)C)O
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 64 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- QSAR
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 20 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- QSAR
- Conclusions:
- EC50 Algae (72 h): 64 mg/l
NOEC Algae (72h): 20 mg/l - Executive summary:
Acute toxicity algae:
Toxicity of the Glycerol 1,3 dimethacrylate (158 mg/L) is predicted from category members using trend analysis based on 13 values within the range 2.25 - 836 mg/L from 13 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 14 experimental values
The predicted value of 158 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the acute toxicity to alga of the different methacrylates and log Kow. The correlation of EC50 was consistent with increasing log Kow therefore the graphic was used to find the EC50 Algae of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05.
A EC50, log (1/mol/l) of 3,55 was read from the y-axis of the diagram which recalculated corresponds to an EC50 of 64 mg/l.
Chronic toxicity algae:
The predicted value of 68,9 mg/l is based on Log Kow 1,16 which is calculated by KowWin. 2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the chronic toxicity to alga of the different methacrylates and log Kow. The correlation of NOEC was consistent with increasing log Kow therefore the diagram was used to read NOEC Algae of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05. A NOEC, log (1/mol/l) of 4,05 was read from the y-axis of the diagram which recalculated corresponds to a NOEC of 20 mg/l.
Reference
Acute toxicity algae:
Toxicity of the Glycerol 1,3 dimethacrylate (158 mg/L) is predicted from category members using trend analysis based on 13 values within the range 2.25 - 836 mg/L from 13 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 14 experimental values
The predicted value of 158 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the acute toxicity to algae of the different methacrylates and log Kow. The correlation of EC50 was consistent with increasing log Kow therefore the graphic was used to find the EC50 Algae of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05.
An EC50, log (1/mol/l) of 3,55 was read from the y-axis of the diagram which recalculated corresponds to an EC50 of 64 mg/l.
Chronic toxicity algae:
The predicted value of 68,9 mg/l is based on Log Kow 1,16 which is calculated by KowWin. 2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the chronic toxicity to algae of the different methacrylates and log Kow. The correlation of NOEC was consistent with increasing log Kow therefore the diagram was used to read NOEC Algae of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05. A NOEC, log (1/mol/l) of 4,05 was read from the y-axis of the diagram which recalculated corresponds to a NOEC of 20 mg/l.
Description of key information
Toxicity of the Glycerol 1,3 dimethacrylate (158 mg/L) is predicted from category members using trend analysis based on 13 values within the range 2.25 - 836 mg/L from 13 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 14 experimental values
The predicted value of 158 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the acute toxicity to alga of the different methacrylates and log Kow. The correlation of EC50 was consistent with increasing log Kow therefore the graphic was used to find the EC50 Alga of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05.
An EC50, log (1/mol/l) of 3,55 was read from the y-axis of the diagram which recalculated corresponds to an EC50 of 64 mg/l.
Chronic toxicity alga:
The predicted value of 68,9 mg/l is based on Log Kow 1,16 which is calculated by KowWin. 2-hydroxy-1,3-propanediyl bismethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2,05. The QSAR prediction was used to create the diagram which shows the correlation of the chronic toxicity to alga of the different methacrylates and log Kow. The correlation of NOEC was consistent with increasing log Kow therefore the diagram was used to read NOEC Algae of 2-hydroxy-1,3-propanediyl bismethacrylate with log Kow 2,05. A NOEC, log (1/mol/l) of 4,05 was read from the y-axis of the diagram which recalculated corresponds to a NOEC of 20 mg/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 64 mg/L
- EC10 or NOEC for freshwater algae:
- 20 mg/L
Additional information
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