Isobutyl isobutyrate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Justification for type of information:

The study was conducted well before GLP or OECD guidelines. Documentation is very limited, but the study was conducted at a leading laboratory to the state of the art at the time.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

no

Test type:

other:

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isobutyl isobutyrate

EC Number:

202-612-5

EC Name:

Isobutyl isobutyrate

Cas Number:

97-85-8

Molecular formula:

C8H16O2

IUPAC Name:

2-methylpropyl 2-methylpropanoate

Test animals

Species:

rat

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Duration of exposure:

6 h

Concentrations:

3.88 or 31.94 mg/l

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

Test subjects were exposed to either 3.88 or 31.94 mg/l for 6 hours and then monitored for 2 weeks.

Results and discussion

Effect levels

Dose descriptor:

LC50

Effect level:

> 3.88 - < 39.14 mg/L air

Based on:

test mat.

Mortality:

2/3 dead at 39.14 mg/l, no deaths at 3.88 mg/l

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

There were 2/3 dead at 39.14 mg/l, no animals were found dead at 3.88 mg/l.

Executive summary:

The LC50 was between 3.88 and 39.14 mg/l.