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EC number: 274-092-8 | CAS number: 69709-01-9
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
log Kow [1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine]: -4 at pH 7(QSAR)
log Kow
[1,1,3,3-tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine]: -4 at pH 7
(QSAR)
log Kow
[methanol]: 0.82 to -0.64
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -4
- at the temperature of:
- 20 °C
Additional information
A predicted log Kow value of 1.2 at 20°C was determined for 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine using a QSAR estimation method. This prediction refers to the unionised form of the substance. The amine group in the substance will protonate in solution and the substance is expected to be only in the ionised form in the environment and in vivo; therefore, the estimated log Kow for the unionised form was corrected for ionisation using the equation provided in the ECHA Guidance R.7a (2008). Log Kow values of -4, -4, -4 and -2.3 at pH 2, pH 4, pH 7 and pH 9 were determined for the substance. The relevant corrected log Kow values are used for assessment purposes.
In contact with water, 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine hydrolyses rapidly to form 1,1,3,3-tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine and methanol.
Similarly, the unionised form of the silanol hydrolysis product; 1,1,3,3-tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine has a predicted log Kow value of -1.9 using a validated QSAR estimation method. The corrected value at pH 2, pH 4, pH 7 and pH 9 is -4.
Methanol has a reported log Kow value of -0.82 to -0.64 (OECD 2004).
Reference:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
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