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Diss Factsheets
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EC number: 210-498-3 | CAS number: 616-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Table 1: Human data
Source |
Observation |
Concentration |
David J. et al., Liver Injury After Oral and Rectal Administration of N-Acetylcysteine for Meconium Ileus Equivalent in a Patient With Cystic Fibrosis, Pediatrics February 1987, VOLUME 79 / ISSUE 2 |
A 3-year old boy was treated with the test via different routes for 3 days. Severe hepatic dysfunction occurred on two occasions after the administration of NAC for the treatment of meconium ileus equivalent. |
TDLo = 8480 mg/kg |
van Zandwijk N. et al., EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst. 2000 Jun 21;92(12):977-86. |
Human, 2-year administration; route not reported |
TDLo = 3650 mg/kg |
Cancer Epidemiology Biomarkers & Prevention,11,167, 2002 |
human, oral administration, 24 weeks |
TDLo = 1.54 g/kg |
Kim J., et al (correspondence). Response to Letter to the Editor on "Effect of N-acetylcysteine on liver recovery after resection. A randomized clinical trial". Journal of Surgical Oncology, (1 Nov 2016) Vol. 114, No. 6, pp. 774. Refs: 2 ISSN: 0022-4790; E-ISSN: 1096-9098 CODEN: JSONAU |
Human, occupational contact dermatitis in adults |
|
Beuhler, Michael C., Dr. (correspondence), Dulaney, Anna R. Further case details regarding IV N-acetylcysteine overdoses. Clinical Toxicology, (November 2011) Vol. 49, No. 9, pp. 878. Refs: 3 ISSN: 1556-3650; E-ISSN: 1556-9519 |
Human, occupational contact dermatitis, effects of overdose |
|
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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