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Diss Factsheets
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EC number: 233-634-3 | CAS number: 10287-53-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 July 1987 to 24 July 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- not precised
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- not precised
- Deviations:
- no
- GLP compliance:
- not specified
- Remarks:
- The study was conducted in accordance with quality assurance procedures.
Test material
- Reference substance name:
- Ethyl 4-dimethylaminobenzoate
- EC Number:
- 233-634-3
- EC Name:
- Ethyl 4-dimethylaminobenzoate
- Cas Number:
- 10287-53-3
- Molecular formula:
- C11H15NO2
- IUPAC Name:
- ethyl 4-(dimethylamino)benzoate
- Test material form:
- other: crystalline/powdery solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 10 to 13 weeks
- Weight at study initiation: 2.2 to 3.0 kg
- Housing: individually housed in metal cages with perforated floors
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Yes; the report states that all rabbits were acclimated to the laboratory environment
ENVIRONMENTAL CONDITIONS
- Temperature: Approximately 19 °C
- Humidity: 30 to 70 % (relative)
- Air changes: Approximately 19 per hour
- Photoperiod:12 hours of artificial light in each 24 hour period (from 07.00 to 19.00 hours)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g moistened with 0.5 mL distilled water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Dorso-lumbar region. Approximately 24 hours prior to application of the test substance, hair was removed with electric clippers exposing an area of skin approximately 10 cm square.
- Coverage: 2.5 cm square; the test material was applied under a 2.5 cm square gauze pad
- Type of wrap if used: The test site was occluded with elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site washed with water
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
- Examinations: Days 1 (30 minutes after patch removal), 2, 3 and 4
SCORING SYSTEM
- Erythema and Eschar Formation
0 = No erythema
1 = Very slight erythema (barely perceptible)
2 = Well defined erythema
3 = Moderate to severe erythema
4 = Severe erythema (beet redness) to slight eschar formation (injuries in depth)
- Oedema Formation
0 = No oedema
1 = Very slight oedema (barely perceptible)
2 = Slight oedema (edges of the area well defined by definite raising)
3 = Moderate oedema (area raised approximately 1 mm)
4 = Severe oedema (area raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- There was no response to treatment in any of the animals throughout the observation period. All scores for erythema and oedema were 0 for all animals at all time points.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not skin irritating
- Conclusions:
- Under the conditions of this study the test material was determined to be non-irritating to the skin.
- Executive summary:
A study was performed to investigate the potential of the test material to cause skin irritation in accordance with the standardised guidelines OECD 404 and EU Method B.4.
Three New Zealand White rabbits were exposed to the test material in a semi-occlusive manner for 4 hours. The hair was clipped to expose skin on the dorso-lumbar region and 0.5 g of the test material was applied under a 2.5 cm² gauze pad, moistened with 0.5 mL of distilled water. The gauze pads were secured with an elastic adhesive dressing for a four-hour exposure period. After the four-hour exposure, the wraps were removed and the test sites were washed with water to remove any residual test material. The test sites were examined for dermal irritation at approximately 30 minutes and at 24, 48 and 72 hours following removal of the patches.
There were no signs of erythema or oedema during the course of the study. The mean erythema and oedema scores were 0.0 and 0.0, respectively. All rabbits scored 0 for both erythema and oedema at each evaluation.
Under the conditions of this study the test material was determined to be non-irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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