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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-716-5 | CAS number: 69-79-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-07-03 to 2017-07-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance Document "Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance” from Oct. 2015
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 470.2 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 4.42 - <= 6
- Conclusions:
- The water solubility of the test item was determined to be 470.2 g/L ± 3.6 %. The result is also applicable for the water free form of the test item.
- Executive summary:
A study was performed according to OECD TG 105 and Regulation (EC) No. 440/2008 method A.6 in order to determine the water solubility of the test item in water by using the flask method (analytical method: HPLC). The mean water solubility was determined to be 470.2 g/L ± 3.6 %. All replicates showed good correspondence. Equilibration was considered to be reached after 1 day. No observations arising doubts concerning the accuracy of the results and the validity of the study were made. The result is also applicable for the water free form of the test item.
Reference
Measurements during Equilibration
The data which was acquired during equilibration time (flask 1A-C, days 1 – 3) is presented in the following table:
Table 3a: Equilibration
Day |
Tempera- |
pH* |
Area |
Measured |
Dilu- |
Mean |
Difference |
1 |
20.0 |
5-6 |
36.533 |
2607.1 |
200 |
477.8 |
- |
34.760 |
34.760 |
||||||
2 |
20.0 |
5-6 |
34.869 |
2501.7 |
200 |
471.8 |
-1.3 |
35.409 |
35.409 |
||||||
3 |
20.0 |
5-6 |
38.228 |
2714.5 |
200 |
499.4 |
5.8 |
36.710 |
36.710 |
* measured with pH-paper
** Recovery rate of the measured QC sample 106.8 % was taken into account
The plateau was considered as reached after 1 day shaking.
Measurements at Plateau
The following table gives the values, which were measured at the plateau.
Table 3b Plateau
Flask |
Temperature |
pH |
Area |
Measured values |
Dilution |
Mean |
Blank |
20.0 |
7* |
Not detectable |
Not detectable |
200 |
< LOQ |
Not detectable |
Not detectable |
|||||
2 |
20.3 |
4.56 |
31.778 |
2305.8 |
200 |
459.4 |
31.490 |
2287.5 |
|||||
3 |
20.3 |
4.45 |
31.154 |
2266.2 |
200 |
445.5 |
29.933 |
2188.9 |
|||||
4 |
20.3 |
4.45 |
32.855 |
2374.0 |
200 |
483.2 |
34.178 |
2457.8 |
|||||
5 |
20.3 |
4.43 |
30.960 |
2253.9 |
200 |
454.7 |
31.573 |
2292.8 |
|||||
6 |
20.3 |
4.42 |
32.704 |
2364.4 |
200 |
469.5 |
32.171 |
2330.6 |
* measured with pH-paper
** measured with pH-meter
The measurements of the days 1, 2 and 3 were included in the calculation of the mean.
Table 3c: Measurements used for Calculation of Solubility
Day | Flask | Concentration | Total Mean | Total Standard Deviation [g/L] |
[g/L] | [g/L] | (RSD* [%]) | ||
1 | 1A | 477.8 | 470.2 | 17.1 (3.6%) |
2 | 1B | 471.8 | ||
3 | 1C | 499.4 | ||
3 | 2 | 459.4 | ||
3 | 3 | 445.5 | ||
3 | 4 | 483.2 | ||
3 | 5 | 454.7 | ||
3 | 6 | 469.5 |
* RSD = relative standard deviation
Description of key information
The water solubility of the test item was determined to be 470.2 g/L ± 3.6 %. The result is also applicable for the water free form of the test item.
Key value for chemical safety assessment
- Water solubility:
- 470.2 g/L
- at the temperature of:
- 20 °C
Additional information
A study was performed according to OECD TG 105 and Regulation (EC) No. 440/2008 method A.6 in order to determine the water solubility of the test item in water by using the flask method (analytical method: HPLC). The mean water solubility was determined to be 470.2 g/L ± 3.6 %. All replicates showed good correspondence. Equilibration was considered to be reached after 1 day. No observations arising doubts concerning the accuracy of the results and the validity of the study were made. The result is also applicable for the water free form of the test item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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