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EC number: 642-981-3 | CAS number: 148465-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Mucorpepsin has been tested in the daphnia immobilisation test. Read-across to subtilisin is applied for the acute toxicity towards fish and read across to beta-N-acetylhexosaminidase for the algal growth inhibition study.
Daphnia immobilisation test: The 48h EC50 value for Mucorpepsin batch PPR 3583 was determined to 398 mg enzyme concentrate dry matter/L, equivalent to 117 mg active enzyme protein/L and the no-observed-effect concentration 42.5 mg enzyme concentrate dry matter/L, equivalent to 12.5 mg active enzyme protein/L.
Read-across from beta-N-acetylhexosaminidase (another hydrolase) gave similar results.
Algal growth inhibition (read across from beta-N-acetylhexosaminidase: ErC50 > 260.7 mg enzyme concentrate dry matter/L (equivalent to 100 mg active enzyme protein/L). NOEC for both growth rate and yield was 65.2 mg enzyme concentrate dry matter/L and LOEC was 130.4 mg enzyme concentrate dry matter/L. Yield EbC50 was 101.7 mg enzyme concentrate dry matter/L.
Fish acute toxicity (read-across from subtilisin): The measured 96-hour LC50 was 15.6 mg enzyme concentrate dry matter/L (measured as 8.2 mg active enzyme protein/L). Measured 100% mortality was 52.6 mg enzyme concentrate dry matter/L (measured as 27.6 mg active enzyme protein/L).
The NOEC was not clearly identified during the definitive test but based on the findings of a range finding test, it was 10.7 mg enzyme concentrate dry matter/L (nominal) (5.6 mg active enzyme protein/L).
The LC50 value from the fish acute toxicity study is used for PNEC derivation.
Additional information
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