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EC number: 204-526-3 | CAS number: 122-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 25 days for evaluating the percentage biodegradability of test chemical (from peer reviewed journal (J. Sanchez Leal et. al., 1994) and handbook (S. Gangolli, 1999)). The study was performed according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). Test chemical conc. used in the study were 2.5 and 10 mg/l, respectively. For the test chemical, the conventional disulphine- blue active substance test (DBAS test) and the dissolved organic carbon (DOC) disappearance method were used for monitoring their biodegradation. In these tests, the total biodegradation or conversion of the substrate toC02,water and biomass, would result in a decrease of both the DBAS and the organic carbon (DOC) values.The percentage degradation of test chemical was determined to be approx. 80 and 50-60% degradation by test material analysis (%degradation) and DOC parameter in 8 to 15 days at conc. of 2.5 mg/l and 20 days at conc. of 10 mg/l, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
Additional information
Biodegradation in water
Various experimental key and supporting studies of the test chemical were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from peer reviewed journal (J. Sanchez Leal et. al., 1994) and handbook (S. Gangolli, 1999),biodegradation experiment was conducted for 25 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). Test chemical conc. used in the study were 2.5 and 10 mg/l, respectively. For the test chemical, the conventional disulphine- blue active substance test (DBAS test) and the dissolved organic carbon (DOC) disappearance method were used for monitoring their biodegradation. In these tests, the total biodegradation or conversion of the substrate toC02,water and biomass, would result in a decrease of both the DBAS and the organic carbon (DOC) values.The percentage degradation of test chemical was determined to be approx. 80 and 50-60% degradation by test material analysis (%degradation) and DOC parameter in 8 to 15 days at conc. of 2.5 mg/l and 20 days at conc. of 10 mg/l, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
In an supporting study from peer reviewed journal (J. Sanchez Leal et. al., 1994), biodegradation experiment was conducted for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 303 A (Simulation test–Aerobic sewage treatment: Coupled unit tests) under aerobic conditions. Test chemical conc. used for the study were 0.5, 1.0, 2.5, 10 and 20 mg/l, respectively. The percentage degradation of test chemical was determined to be 95-100 and > 75% degradation by test material analysis (%degradation) parameter in 7 days at conc. of 10 and 20 mg/l, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test). Test chemical conc. used for the study were 5 and 40 mg/l, respectively. The percentage degradation of test chemical was determined to be ≥ 90 and ≥ 95% degradation by test material analysis (%degradation) parameter after a period of 24 and 48 hrs, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature
In an supporting study, biodegradation study was conducted for 25 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test) under aerobic conditions. Test chemical conc. used in the study was 5 mg/l. Test chemical content was analyzed by the DBAS method and primary biodegradation was stated as the percentage of DBAS removal. DOC measurements were periodically performed and ultimate biodegradation was stated as the percentage of DOC removal. Ultimate biodegradation or mineralization was determined by DOC removal. DOC determination involves a sample membrane filtration to remove bacterial cells. To check whether the surfactant removal was really due to its biodegradation, TOC measurements were also carried out. TOC and DOC were determined by the combustion-infrared method using a TOC Analyzer (Shimadzu TOC-5050). For the DOC determinations, samples were subjected to membrane filtration (0.22mm pore size) and decarbonation by acidification with HCl prior to being analyzed by the TOC Analyzer. The percentage degradation of test chemical was determined to be 30 and 0% degradation by test material analysis (%degradation) & DOC parameter in 28 and 20 days, respectively. Thus, based on percentage degradation, test chemical is considered to be primary inherentlybiodegradable in nature.
For the target chemical from peer reviewed journal (Garcia et al, 1999), an experiment was performed to determine biodegradability of test chemical in anaerobic condition. The anaerobic sludge and the test chemical were incubated in 250 mL pressure-resistant glass bottles at 35 oC. The bottles were fitted with gas tight septa and aluminium crimp seals. After sealing the vessels and incubating them for about 1 hour at 35oC, excess gas was released to the atmosphere and the incubation proceeded in the dark. The evolved pressure was measured weekly with a digital manometer connected to a syringe needle which was inserted through the septum and excess of biogas was released. The increase in headspace pressure in the closed bottles was used to follow the biodegradation process. At the end of the test, after allowing the sludge to settle, vessels were opened and the dissolved part of carbon dioxide was determined as the concentration of inorganic carbon (IC) in the clear supernatant. For the measurements of inorganic carbon (IQ a carbon analyzer was used (Shimadzu TOC-5050). At the end of the test period, specific analyses of cationic surfactant both in the supematant Liquor and in the settled sludge were carried out to determine the primary biodegradation extent. The analytical procedure included diverse steps of extraction, clean-up and concentration of cationic surfactant [IO] and final quantification by the DBAS method. The biodegradability of test chemical is determined to be 28 % by using anaerobic sludge as inoculums in anaerobic condition and gas production as parameter in 200 days. This percent degradability value in 200 days indicates that test chemical is inherently biodegradable.
On the basis of overall results for test chemical(from peer reviewed journals and handbook), it can be concluded that the test chemicalcan be expected to be readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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