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EC number: 255-785-4 | CAS number: 42373-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-02-13 to 1979-11-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF test
- GLP compliance:
- no
- Test type:
- other: BASF method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- EC Number:
- 255-785-4
- EC Name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- Cas Number:
- 42373-04-6
- Molecular formula:
- C19H17N4S.Cl
- IUPAC Name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- Test material form:
- solid
1
- Specific details on test material used for the study:
- 0.5-50% solution in 0.5% aqueous carboxymethylcellulose preparation
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% aqueous carboxymethylcellulose preparation
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5 to 50% - Doses:
- top dose: 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to 1225 mg/kg bw act. ingr.
- Mortality:
- protracted death, no further data on mortality provided
- Clinical signs:
- During first week bad general condition observed. Further adverse clinical signs of toxicity were: apathy, hyperesthesia, aggressive, ataxia, tremor, muscle twitches, clonic convulsion, diarrhoea and salivation, spastic movement
- Body weight:
- Body weight loss during the first week of experiment
- Gross pathology:
- Animals, which died during observation period: Heart: dilatation (right), acute hyperemia; intestine: atonic, diarrheic content; stomach: dilated, substance-filled
Sacrificed animals: no adverse effects
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In an acute oral toxicity study, the LD50 of the test item was determined to be 3500 mg/kg bw in rats.By extrapolating the concentration of 50% of the test item to 100% (undiluted), and furthermore to 100% dye content, the calculated LD50 can be considered to be 1225 mg/kg bw. Thus, the substance is considered to be classified as Acute Toxic Cat. 4.
- Executive summary:
In an acute oral toxicity study, rats were given a single oral dose of 0.5 -50% suspension of the test item diluted in 0.5% aqueous carboxymethylcellulose. An unknown number of animals died during the study. At the first week a bad in the general condition was observed. Moreover, adverse clinical signs of toxicity were observed, such as apathy, hyperesthesia, aggressive, ataxia, tremor, muscle twitches, clonic convulsion, diarrhoea, salivation, and spastic movements. A body weight loss during the first week of experiment was reported. Based on the results from this study, the LD50 of the test item was determined to 3500 mg/kg in rats. By extrapolating the concentration of 50% of the test item to 100% (undiluted), and furthermore to 100% dye content, the calculated LD50 can be considered to be 1225 mg/kg bw. Thus, the substance is considered to be classified as Acute Toxic Cat. 4.
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