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EC number: 700-881-8 | CAS number: 83145-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-11-22 to 2011-11-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant skin irritation study for lithium bis(oxalato)borate was used for read across and evaluation of skin irritation properties of potassium bis(oxalato)borate on the basis of structural similarity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 24th April 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 16th June 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 244761-29-3
- EC Number:
- 607-383-9
- Cas Number:
- 244761-29-3
- IUPAC Name:
- 244761-29-3
- Reference substance name:
- Lithium bis(oxalato)borate
- EC Number:
- 456-990-3
- EC Name:
- Lithium bis(oxalato)borate
- IUPAC Name:
- lithium bis(oxalato)borate
- Test material form:
- other: solid
- Details on test material:
- SMILES: O=C1O[B-]2(OC1=O)OC(=O)C(=O)O2.[Li+]
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: S & K LAP Kft. 2173 Kartal, Császár út 135, HUNGARY
- Age at study initiation: Young adult rabbits, 10 weeks old
- Weight at study initiation: 3191-3340 g
- Housing: Animals were housed individually in metal cages.
- Diet (e.g. ad libitum): P. Strengthened Female Hare Mixed diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 19 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 30 - 70 % (rel.)
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin served as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, 72 hours
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: back and flanks
- coverage: an approximately area of 6 cm^2 of intact skin
- Type of wrap if used: plastic wrap
REMOVAL OF TEST SUBSTANCE
- Washing (if done): body temperature water used
- Time after start of exposure: 4 hours
SCORING SYSTEM: by Draize et al. (1959)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: very slight erythema and crust was found after 24 h
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: very slight erythema was detected after 24 and 48 h
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #2
- Time point:
- other: 24, 48. 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: very slight erythema after 24 h
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Read across for evaluation of skin irritation properties of potassium bis(oxalato)borate from the skin irritation in vivo study results of lithium bis(oxalato)borate is justified on the basis of structural similarity of the substances. The bis(oxalato)borate salt part [B(C2O4)2] is the same in both substances and only the cationic part of salts differ (lithium or potassium). Both lithium and potassium belong to alkali-metals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the skin irritation study of lithium bis(oxalato)borate the test substance was not irritating to the intact skin of New Zealand white rabbits.
Based on structural similarity, the result can be used for read across when evaluating skin irritation properties of potassium bis(oxalato)borate. The result can be used for classification purposes. For risk assessment, also potassium bis(oxalato)borate can be regarded as not irritating to skin. See also attachment in section 13 (Analogue approach justification). - Executive summary:
The acute skin irritation study of the test item lithium bis(oxalato)borate (LiBOB) was performed in New Zealand White rabbits according to OECD guideline 404 and EU method B.4. The irritation effect of the test item was evaluated according to the Draize method. The test item was administered in pure state, in a single dose of 0.5 g, to the hairless skin of three experimental rabbits. The untreated skin of each animal served as control. After 4 hours the rest of the test item was removed with water. The animals were examined at 1, 24, 48 and 72 hours after the patch removal. One hour after the patch removal very slight and well defined erythema and very slight edema were observed. 24 hours after the patch removal very slight erythema was found in all animals and crust were recorded in one animal. 72 hours after the patch removal no primary irritation symptoms, like erythema and edema or other signs occurred on the treated skin surfaces, so the study was terminated at this time. The animal’s individual mean scores (considering readings at 24, 48 and 72 hours after the patch removal) were as follows:
- erythema: 0.33, 0.66, 0.33
- edema: 0.00, 0.00, 0.00
During the study the control area was symptom-free. General state and the behavior of animals were normal throughout the study period. There were no notable body weight changes during the contact and observation period. The observed symptoms were evaluated as fully reversible alterations. From this follows lithium bis(oxalato)borate is non irritating to the intact skin of New Zealand white rabbits. (TOXICOOP, 2012).
Based on structural similarity, the result can be used for read across when evaluating skin irritation properties of potassium bis(oxalato)borate. Consequently, also potassium bis(oxalato)borate can be regarded as not irritating to skin.
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