Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-940-4 | CAS number: 2014-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Trichlortoluene Isomers: A 28-Day Feeding Study in the Rat
- Author:
- I. Chu, S. Y. Shen, D. C. Villeneuve, V. E. Secours
- Year:
- 1 984
- Bibliographic source:
- J. Envirom. Sci. Health B19(2)
Materials and methods
- Principles of method if other than guideline:
- See below
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-dichlorobenzyl chloride
- EC Number:
- 217-940-4
- EC Name:
- 2,6-dichlorobenzyl chloride
- Cas Number:
- 2014-83-7
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- 2,6-dichlorobenzyl chloride
- Details on test material:
- purchades from Aldrich Chemical Co.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 13 groups of 10 male/female each, acclimatized for one week, 12 h light/dark cycle, 20 +- 2 °C, 40 +-5% rh.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Details on oral exposure:
- Test substance was dissolved in corn oil and mixed with diet.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm
- Dose / conc.:
- 0.5 ppm
- Dose / conc.:
- 5 ppm
- Dose / conc.:
- 50 ppm
- Dose / conc.:
- 500 ppm
- No. of animals per sex per dose:
- 10 male and female each
- Control animals:
- yes, concurrent vehicle
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- Body weight and food consumption were determined weekly, clinical observations made daily.
- Sacrifice and pathology:
- Gross examinations at necropsy
- Other examinations:
- Serum analysiss, hepathic mixed function oxidases
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At 500 ppm increades ADPM activities in male rats.
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Mild changes in observes organs liver, kidney, thyriod gland.
Liver: Mild regualr and irregular lobular patterns, heptatocytes had mild anisokaryosis associated with pyknosis, and occasionally necrotic hepatocytes were observed.
Kidney: The renal changes consisted of an accumulation of eosinophilic intracytoplysmic inclusion in the epithelium of proximal tubules associated with focal glomerular adhesions and interstitial scarring due to spontaneous aging process.
Thyroids: Reduction in follicular size and colloid densitiy. The epithelium cells became columnar and thickened with focal and multifocal angular collapse of follices. Focal and multifocal pypillars profilerations and focal vacuolations.
No residual substance in liver and fat at any dose. - Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
Applicant's summary and conclusion
- Conclusions:
- The substance showed a low order of subacute oral toxixity in male and female rats. No accumulation in tissues due to exposure was observed.
- Executive summary:
Groups of 10 male and 10 female rats were fed 2,6-dichlorobenzylchloride in their diet at 0, 0.5, 5. 50 and 500 ppm (corresponds to 0.048 - 46 mg/kg bw day in males and 0.053 - 53 mg/kg bw/day in females) for 28 days. Growth rate and food consumption were not affected by treatment. No deaths occured. Mild biochemical changes occured in male rats. Hepatic microsomal aminopyrine N-demethylase activities were increased in male rats at 500 ppm. Hematological parameters were not affected by treatment. Mild histological changes were seen in the liver, kidney and thyroid of treated rats. Data suggest that 2,6-dichlorobenzylchloride possesses a low order of oral toxicity in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.